头孢菌素类药物在环境中的行为及残留研究进展

Research progress on the fate and residues of cephalosporins in the environment

头孢菌素类药物抗菌谱广、毒性小,在畜禽养殖业中使用十分广泛。当头孢菌素类药物通过工业生产中污水的排放,或经动物给药后的粪便排放等方式排入土壤、污水中时,会使得环境微生物的耐药基因(ARGs)丰度增加,增加环境中细菌的耐药性,从而威胁到抗生素对细菌感染的治疗。本文对头孢菌素类抗生素在环境(土壤、粪肥、水体)中的吸附、迁移、降解等行为、目前的残留情况以及对环境微生态的影响进行综述,引起人们对头孢菌素类抗生素在环境中的残留危害的重视。

Cephalosporins have a wide spectrum of antibacterial activity and low toxicity. They are widely used in animals. When the cephalosporins are discharged into the soil and sewage through the discharge of sewage from industrial production or by the discharge of feces after animal administration, the abundance of environmental microbial resistance genes(ARGs) and bacteria resistance in the environment will be increased. Thus, it will reduce the success of antibiotic treatment of bacterial infections. In this article, the adsorption, migration, degradation and other behaviors of cephalosporin antibiotics in the environment(soil, manure, and water), current residues and effects on environmental micro-ecology are reviewed, to attracted people’s attention to the residual harm of cephalosporin antibiotics in the environment.