抗新型冠状病毒肺炎中药的研究进展

Research progress of traditional chinese medicine against COVID-19

新型冠状病毒肺炎(Coronavirus disease 2019,COVID-19)在世界范围内大流行以来,已成为全球公共卫生重大事件。目前COVID-19的应对方案主要包括疫苗、抗体、化学药物及中药。其中,中药在抗COVID-19过程中发挥了积极作用。单味中药如金银花、甘草、穿心莲、黄芩、虎杖、大黄、连翘、黄芪,中药单体如槲皮素、甘草酸、木犀草素、山奈酚、黄芩素等有潜在的抗COVID-19作用。另外,中药方剂如连花清瘟颗粒(胶囊)(LHQW)、金花清感颗粒(JHQG)、清肺排毒汤(QFPD)、宣肺败毒颗粒(XFBD)等国家诊疗方案推荐的中药配方对于COVID-19的防治具有较好的疗效。本文总结了目前抗COVID-19中药的研究进展,探讨其抗病毒分子机制,旨在为中药治疗COVID-19提供理论依据和新思路,加速中药在COVID-19救治过程中的积极应用。

The transmission and pandemic of coronavirus disease 2019(COVID-19)poses serious threat to public health safety and global economy.Current countermeasures against COVID-19 include vaccines,antibodies,chemical drugs and traditional Chinese medicine(TCM).Among them,TCM plays a key role in the anti-COVID-19 process.Single Chinese herbal medicines such as honeysuckle,licorice,andrographis paniculata,scutellaria baicalensis,polygonum cuspidatum,rhubarb,forsythia suspensa,astragalus mem branaceus and Chinese herbal monomer such as quercetin,glycyrrhizic acid,luteolin,kaempferol and baicalein etc show potential anti-SARS-CoV-2 effects.In addition,TCM prescriptions such as Lianhua Qingwen Granules(Capsules)(LHQW),Jinhua Qinggan Granules(JHQG),Qingfei Paidu Decoction(QFPD),Xuanfei Baidu Granules(XFBD)and other TCM prescriptions recommended by Chinese national diagnosis and treatment program exhibit potent effects on the prevention and treatment of COVID-19.This review summarized the progress and protential molecular mechanisms of anti-SARS CoV-2 TCM,aiming to provide theoretical basis,prospects and accelerate the active application of TCM for the treatment of COVID 19.