防御素在抗结核分枝杆菌感染中的作用机制研究进展

Research progress on the mechanism of defensin against Mycobacterium tuberculosis infection

防御素是广泛分布于生物界的一类富含半胱氨酸的内源性阳离子抗菌肽,在抵抗病原微生物入侵及调节机体免疫功能等方面发挥重要作用。研究发现,防御素对细菌、真菌或病毒等均具有杀灭作用,其在抗结核分枝杆菌感染中也展现出突出优势。防御素独特的抗菌机理可以破坏结核分枝杆菌的细胞壁、细胞膜等生物学结构,从而抑制结核分枝杆菌。本文对防御素的分子结构、生物学作用、抗结核作用及机制予以综述。

Defensins are cysteine-rich endogenous cationic antibacterial peptides widely distributed in the biological world, which play an important role in resisting the invasion of pathogenic microorganisms and regulating the immune function of the body. It has been found that defensins have killing effects on bacteria, fungi and viruses, and they also have shown outstanding advantages over the fighting against M. tuberculosis infection.The unique antibacterial mechanisms of defensins can destroy the cell wall, cell membrane and other biological structures of M. tuberculosis,thereby inhibiting M. tuberculosis. In this review, we summarized the molecular structure, biological effects, anti-tuberculosis effects and mechanisms of defensins.