摘要
防御素是广泛分布于生物界的一类富含半胱氨酸的内源性阳离子抗菌肽,在抵抗病原微生物入侵及调节机体免疫功能等方面发挥重要作用。研究发现,防御素对细菌、真菌或病毒等均具有杀灭作用,其在抗结核分枝杆菌感染中也展现出突出优势。防御素独特的抗菌机理可以破坏结核分枝杆菌的细胞壁、细胞膜等生物学结构,从而抑制结核分枝杆菌。本文对防御素的分子结构、生物学作用、抗结核作用及机制予以综述。
Defensins are cysteine-rich endogenous cationic antibacterial peptides widely distributed in the biological world, which play an important role in resisting the invasion of pathogenic microorganisms and regulating the immune function of the body. It has been found that defensins have killing effects on bacteria, fungi and viruses, and they also have shown outstanding advantages over the fighting against M. tuberculosis infection.The unique antibacterial mechanisms of defensins can destroy the cell wall, cell membrane and other biological structures of M. tuberculosis,thereby inhibiting M. tuberculosis. In this review, we summarized the molecular structure, biological effects, anti-tuberculosis effects and mechanisms of defensins.
作者
高雪涵
朱杰华
刘利萍
蒙祖迪
亓凯
卫麟娜
秦欢
罗军敏
GAO Xue-han;ZHU Jie-hua;LIU Li-ping;MENG Zu-di;QI Kai;WEI Lin-na;QIN Huan;LUO Jun-min(Department of Immunology,School of Basic Medical Sciences,Zunyi Medical University,Zunyi 563000,Guizhou,China;Department of Medical Laboratory,Affiliated Hospital of Zunyi Medical University;Department of Microbiology,Zunyi Medical College,Zunyi Medical University)
出处
《中国病原生物学杂志》
CSCD
北大核心
2023年第1期121-125,共5页
Journal of Pathogen Biology
基金
国家自然科学基金项目(No.81860291)。
关键词
防御素
抗菌肽
结核分枝杆菌
机制
免疫应答
综述
Defensin
antimicrobial peptides
Mycobacterium tuberculosis
mechanism
immune response
review