多瘤病毒感染及人乳头瘤状病毒感染与食管癌组织病理学特征的关系

Relationship between polyomavirus infection and human papillomavirus infection and histopathological characteristics of esophageal carcinoma

目的分析多瘤病毒感染、人乳头瘤病毒(HPV)感染与食管癌组织病理学特征的相关性。方法选取2017年11月-2019年12月在郑州大学附属肿瘤医院接受食管癌手术的200例研究对象,其中手术病理证实ESCC 104例(ESCC组),食管癌前期病变37例(癌前病变组),病理证实切缘肿瘤组织阴性,无组织改变患者59例(对照组);统计各组尿液多瘤BK病毒(BKV)、多瘤JC病毒(JCV)及组织HPV感染率(BKV+或JCV+、HPV16+或HPV18+);分析不同临床特征的食管癌患者多瘤病毒感染BKV、JCV及HPV感染情况,多元逐步回归分析多瘤病毒感染、HPV感染与食管癌的关系。结果ESCC组多瘤病毒感染率及BKV+JCV-、JCV+BKV-、BKV+JCV+,HPV16+、HPV18+、HPV16+HPV18+比例均高于食管癌前病变组、对照组(P<0.05);不同临床分期、分化程度的食管癌患者多瘤病毒感染及HPV感染差异有统计学意义,淋巴结转移的食管癌患者中多瘤病毒感染、HPV感染率高于无淋巴结转移患者(P<0.05);多元逐步回归分析,结果显示多瘤病毒感染与临床分期、分化程度相关(P<0.05);HPV感染与临床分期、分化程度、淋巴结转移相关(P<0.05)。结论多瘤病毒感染、HPV感染与食管癌临床分期、分化程度等存在密切关联,值得临床重视。

OBJECTIVE To analyze the correlation between polyomavirus and human papillomavirus(HPV)infection and histopathological characteristics of esophageal cancer.METHODS Two hundred patients who underwent operation for esophageal cancer in the Affiliated Cancer Hospital of Zhengzhou University between Nov 2017 and Dec 2019 were recruited.They were divided into 104 cases with surgical pathology confirmed esophageal squamous cell carcinoma in the ESCC group,37 cases of esophageal precancerous lesions with pathology confirmed negative tumor tissue at the margin in the precancerous lesion group and 59 cases without tissue changes in the control group.Surgical pathology confirmed 104 cases of esophageal squamous cell carcinoma(ESCC)(ESCC group).The urine positive rates of BK virus(BKV),JC virus(JCV)and HPV virus(BKV+or JCV+,HPV16+or HPV18+)in each group were calculated.The infection rates of BKV,JCV and HPV in patients with different clinical characteristics of esophageal cancer were analyzed.Multiple stepwise regression analysis of the relationship between polyomavirus infections and HPV infection and esophageal cancer was performed.RESULTS The proportions of BKV+,JCV+,BKV+JCV+,BKV+or JCV+,HPV16,HPV18,HPV16+HPV18+,HPV16+and HPV18+in urine specimens of esophageal cancer group were significantly higher than those in the precancerous lesion group and the control group(P<0.05).With the increase of clinical stage and the decrease of differentiation degree,The rates of polyomavirus infection and HPV infection in esophageal cancer group were significantly different in patients with different clinical stages and differentiation degree.The rates of polyomavirus and HPV infection in esophageal cancer patients were significantly higher than those without lymph node metastasis(P<0.05).Multiple stepwise regression analysis showed that polyomavirus infection was significantly related to clinical stage and differentiation degree(P<0.05).HPV infection was significantly related to clinical stage,differentiation degree,and lymph node metastasis(P<0.05).CONCLUSION Polyomavirus infection and HPV infection are closely related to clinical stage and differentiation degree of esophageal cancer,which deserves clinical attention.