乳腺癌抗雌激素耐药基因4在肿瘤中的表达及调控作用研究进展

Progress on Expression of LncRNA Breast Cancer Antiestrogen Resistance 4 and Its Regulatory Effects

长链非编码RNA(long non-coding RNA,lncRNA)是长度超过200个核苷酸的不编码蛋白的RNA。随着lncRNA研究的不断深入,发现其在恶性肿瘤发生发展中起到重要的调控作用。乳腺癌抗雌激素耐药基因4(breast cancer anti-estrogen resistance 4,BCAR4)是在研究乳腺癌中抵抗雌激素耐药基因时发现的一种lncRNA,其在诸多肿瘤中表达异常并能调控肿瘤的增殖、侵袭和转移等恶性生物学行为。对BCAR4的深入研究有助于推动相关肿瘤早期诊断、靶向治疗和预后评估的发展。该文就BCAR4在肿瘤发生发展中的作用及潜在分子机制作一综述。

Long non-coding RNA(lncRNA)with a length more than 200 nucleotides(nt)is unable to encode protein.It has been recognized that lncRNA plays important regulatory roles in occurrence and progression of many malignant tumors.Breast cancer anti-estrogen resistance 4(BCAR4)is a kind of lncRNA found in study of estrogen-resistant genes in breast cancer,and it is dysregulated in various carcinomas and can regulate the malignant biological behaviors including proliferation,invasion and metastasis of cancer cells.The in-depth study of BCAR4 is helpful to promote the development of early diagnosis,targeted therapy and prognostic assessment of relevant tumors.This article reviews the function and potential regulatory mechanisms of BCAR4 in tumorigenesis and development.