大剂量普米克令舒雾化吸入治疗对毛细支气管炎患者症状改善及肺功能的影响

Effect of High-dose Pulmicort Nebulizer Inhalation on Symptom Improvement and Lung Function in Patients with Bronchiolitis

目的分析在毛细支气管炎患者中雾化吸入大剂量普米克令舒对肺功能和症状的影响。方法纳入2020年1月-2021年11月本院收治的80例毛细支气管炎患儿,以抽签法分为两组(甲组,常规治疗+雾化吸入大剂量普米克令舒,40例;乙组,常规治疗+雾化吸入小剂量普米克令舒,40例),分析肺功能、症状改善时间、不良反应、疗效。结果乙组症状改善时间长于甲组(P<0.05)。乙组不良反应总发生率与甲组对比无统计学意义(P>0.05)。乙组治疗总有效率低于甲组(P<0.05)。乙组与甲组治疗前肺功能指标差异不显著(P<0.05)。乙组与甲组治疗后肺功能指标优于治疗前(P<0.05)。甲组治疗后肺功能指标优于乙组治疗后(P<0.05)。结论雾化吸入大剂量的普米克令舒可提高毛细支气管炎的疗效,明显促进症状缓解、改善肺功能,同时安全性比较高。

Objective To analyze the effects of nebulized inhalation of large doses of Pulmicort Resul on lung function and symptoms in patients with bronchiolitis.Methods 80 children with bronchiolitis from January 2020 to November 2021,were enrolled and they were divided into two groups by lottery(group A,conventional treatment+nebulized high-dose pulmicort,40 cases;group B,conventional treatment+aerosol inhalation of low-dose pulmicort,40 cases),to analyze lung function,symptom improvement time,adverse reactions,and efficacy.Results The improvement time of symptoms in group B was longer than that in group A(P<0.05).The total incidence of adverse reactions in group B was not statistically significant compared with group A(P>0.05).The total effective rate of treatment in group B was lower than that in group A(P<0.05).There was no significant difference in lung function indexes between group B and group A before treatment(P<0.05).The lung function indexes of group B and group A after treatment were better than those before treatment(P<0.05).The lung function indexes of group A were better than those of group B after treatment(P<0.05).Conclusion Aerosol inhalation of large doses of Pulmicort Respules can improve the curative effect of bronchiolitis,significantly promote symptom relief,improve lung function,and is relatively safe.