心力衰竭患者cTnT、hs-CRP、NT-proBNP联合诊断及预后判定的价值

Clinical Value of cTnT,hs-CRP and NT-proBNP combined Examination and Prognosis Evaluation for Heart Failure Patients

目的分析心肌肌钙蛋白T(cTnT)、高敏C反应蛋白(hs-CRP)以及氨基末端B型脑钠肽前体(NT-proBNP)联合用于心力衰竭诊断、预后判断的作用。方法选择本院收治的60例心力衰竭患者为研究主体,将其作为实验组,研究开始于2019年5月,于2020年5月完成。全部患者分别在进入医院时、治疗第5天以及出院时开展血清cTnT、hs-CRP、NT-proBNP水平检测,并对其开展为期一年的随访,分析其心脏事件复发情况。另外选择同时期在本院进行健康体检的60例体检者作为常规组。比较实验组病患入院时与常规组指标水平;比较治疗前后实验组患者指标水平;比较实验组病患入院时单一指标检测与联合检测的准确度;对比出现心脏事件与未出现心脏事件病患指标水平。结果实验组病患入院时cTnT、hs-CRP、NT-proBNP水平均高于常规组,并且伴随心功能等级的提升,上述指标水平呈逐渐升高趋势(P<0.05)。治疗5d、出院时实验组病患cTnT、hs-CRP、NT-proBNP水平均低于入院时(P<0.05)。实验组患者入院时联合检测准确度高于cTnT、hs-CRP、NT-proBNP单一检测(P<0.05)。未出现心脏事件组患者cTnT、hs-CRP、NT-proBNP水平均低于出现心脏事件组(P<0.05)。结论心力衰竭病患cTnT、hs-CRP以及NT-proBNP水平均有显著升高,开展联合检测能够提升诊断准确性,并且对疾病预后进行判断,发挥一定干预作用。

Objective To analyze the clinical value of cardiac troponin T(cTnT),hypersensitivity C-reactive protein(hs-CRP)and N-terminal pro-brain natriuretic peptide(NT-proBNP)combined examination and prognosis evaluation for heart failure patients.Methods 60 heart failure patients treated from May 2019 to May 2020 in our hospital were chosen as experimental group.Upon admission,after 5d of treatment and upon discharge,serum cTnT,hs-CRP and NT-proBNP levels were measured.During one-year follow-up visit,the recurrence rates of cardiac events were recorded.Over the same time period,60 healthy checkups were chosen as routine group.Contrast results were obtained through clinical indicators upon admission for two groups,clinical indicators of experimental group before and after therapy,diagnosis accuracy of experimental group based on single indicator and combined indicators and clinical indicators between patients with and without cardiac events.Results Upon admission,cTnT,hs-CRP and NT-proBNP levels in the experimental group were higher than routine group;with the higher cardiac function grading,relevant indicators showed a rising tendency(P<0.05);after 5d of treatment and upon discharge,cTnT,hs-CRP and NT-proBNP levels in the experimental group were lower than those upon admission(P<0.05);upon admission,the diagnosis accuracy of combined examination in the experimental group was higher than that based on cTnT,hs-CRP or NT-proBNP single examination(P<0.05);cTnT,hs-CRP and NT-proBNP levels for patients without cardiac events were lower than patients with cardiac events(P<0.05).Conclusion cTnT,hs-CRP and NT-proBNP levels are remarkably increased for heart failure patients;the combined examination can increase the diagnosis accuracy and prognosis evaluation values.