糖皮质激素治疗急性多发性硬化临床疗效分析

Clinical Effect Analysis of Glucocorticoid in Treatment of Acute Multiple Sclerosis

目的通过糖皮质激素治疗多发性硬化(multiple sclerosis,MS)临床疗效分析,探究糖皮质激素治疗多发性硬化(multiple sclerosis,MS)临床效果,进而在多发性硬化(multiple sclerosis,MS)临床治疗中推广和应用效果更为优良的糖皮质激素治疗法。方法选取2012年2月-2019年2月到我院就诊的40例急性多发性硬化(multiple sclerosis,MS)患者,随机分为实验组(20例)与对照组(20例)。实验组应用糖皮质激素治疗,通过使用静脉滴注甲基强的松龙;对照组应用米托蒽醌药物与氯化钠融合进行注射。对比两组治疗有效率、患者治疗前后EDSS评分变化,患者治疗满意度以及治疗后两组多发性硬化(multiple sclerosis,MS)患者出现的不良反应。结果治疗效果、满意度、神经功能能量表(EDSS)评分变化结果,实验组优于对照组(P<0.05);治疗干预后,两组患者均出现不良反应,实验组出现不良反应少于对照组(P<0.05)。结论使用糖皮质激素中甲基强的松龙有效治疗急性多发性硬化(multiple sclerosis,MS)患者临床症状,改善患者神经恢复效果,患者满意度与临床价值更高。

Objective To explore clinical effect of glucocorticoid in treatment of multiple sclerosis(MS)based on clinical effect analysis of glucocorticoid in treatment of multiple sclerosis(MS),promote and apply glucocorticoid therapy with better effect in clinical treatment of multiple sclerosis(MS).Methods The paper chose 40 cases acute multiple sclerosis(MS)patients in to our hospital from February 2012 to February 2019,and divided them into experimental group(20 cases)and control group(20 cases)randomly.Experimental group was treated with glucocorticoid by intravenous drip of methylprednisolone,and control group with mitoxantrone and sodium chloride injection.Effective rate,EDSS score changes before and after treatment,treatment satisfaction degree and adverse reactions of multiple sclerosis(MS)were compared between two groups.Results Treatment effect,satisfaction degree and scores change of neurological function energy scale(EDSS)in experimental group were better than control group.After treatment intervention,adverse reactions occurred in both groups,2 cases in experimental group,7 cases in control group,5 cases more in control group.Conclusion Methylprednisolone in glucocorticoid can treat clinical symptoms of acute multiple sclerosis(MS)patients,improve effect of nerve recovery effectively,which can achieve high satisfaction degree of patient and clinical value.