泌乳素水平与肉芽肿性小叶性乳腺炎发病的相关性分析

Analysis of the Correlation between the Level of Prolactin and the Onset of Granulomatous Lobular Mastitis

目的分析泌乳素(PRL)水平与肉芽肿性小叶性乳腺炎(GLM)的相关性。方法病例组选自我院2018年7月-2021年6月诊断为GLM的86例女性患者,另选同期在我院接受体检的45例健康女性为对照组。描述病例组临床病理学情况,比较病例组与对照组实验室指标,对病例组PRL与其他实验室指标进行两两相关分析。结果GLM病变侧以单侧为主,左、右侧比例相近。病变象限以外上和内上居多。就诊时主诉最多的病理特征是乳房肿块,其次是乳房局部疼痛和乳头溢液。临床分期以脓肿期居多,其次溃后期。病例组WBC、N、CRP、IL-4、IL-6和PRL水平均显著高于对照组(P<0.05)。病例组PRL与WBC、N相关,WBC与N、IL-4、IL-6相关,N与IL-6相关,IL-4与IL-6相关,其他指标间相关性很弱。结论GLM患者炎性反应明显,并且PRL水平可反映GLM炎性状况。

Objective Analyze the correlation between the level of prolactin(PRL)and granulomatous lobular mastitis(GLM).Methods The case group was selected from 86 female patients diagnosed with GLM from July 2018 to June 2021 in our hospital,and 45 healthy women who received physical examination in our hospital during the same period were selected as the control group.Describe the clinical pathology of the case group,compare the laboratory indicators of the case group and the control group,and perform a pairwise correlation analysis on the PRL of the case group and other laboratory indicators.Results The lesion side of GLM is mainly unilateral,and the ratio of left and right sides is similar.The upper and inner upper quadrants of the lesion are mostly.The most complained pathological feature during the visit was breast lumps,followed by local breast pain and nipple discharge.The clinical stage is mostly abscess stage,followed by late ulceration stage.The levels of WBC,N,CRP,IL-4,IL-6 and PRL in the case group were significantly higher than those in the control group(P<0.05).In the case group,PRL is related to WBC and N,WBC is related to N,IL-4,IL-6,N is related to IL-6,IL-4 is related to IL-6,and the correlation between other indicators is weak.Conclusion The inflammatory response of GLM patients is obvious,and the level of PRL can reflect the inflammatory condition of GLM.