坎地沙坦与美托洛尔治疗慢性充血性心衰的临床疗效分析

Clinical Analysis of Candesartan and Metoprolol in Treating Congestive Chronic Heart Failure

目的探讨美托洛尔+坎地沙坦治疗充血性慢性心力衰竭(CHF)患者的临床效果。方法将66例充血性CHF患者作为本次研究对象,按照电脑盲选法将其分为参照组(采用常规治疗+坎地沙坦治疗)与试验组(采用美托洛尔+坎地沙坦治疗),每组各33例,所有患者均于2020年1月-2021年1月收治我院,对比两组治疗效果。结果试验组治疗总有效率(93.94%)高于参照组(75.76%),对比存在差异性(P<0.05);两组各项心功能改善情况对比中,试验组左心室短轴缩短率(LVE)F高于参照组,左心质量指数(LVMI)、左心室收缩末期内径(LVESD)、左室内径(LVEED)、左心房舒张期内径(LADD)均低于参照组,对比存在差异性(P<0.05);两组B型利钠肽原(PRO-BNP)指标对比中,试验组优于参照组,差异存在对比性(P<0.05);试验组不良反应发生率(18.18%)虽低于参照组(27.27%),但组间未存在差异(P<0.05);在生活质量综合评定量表(GQOLI)对比中,试验组高于参照组,差异存在对比性(P<0.05)。结论对充血性CHF患者应用美托洛尔+坎地沙坦治疗,在提高临床治疗效果的同时,还能够有效改善患者心功能与PRO-BNP指标,具有一定的治疗安全保障,同时,能够有效提高其生活质量,促进其病情恢复,值得运用与推广。

Objective To discuss the clinical effects of metoprolol and candesartan in treating congestive chronic heart failure(CHF).Methods 66 congestive CHF patients treated from January 2020 to January 2021 in our hospital were selected and divided into reference group(n=33)and experimental group(n=33)according to random picking method.The reference group took the routine therapy and candesartan;the experimental group took metoprolol and candesartan.Curative effects were elucidated.Results The total effective treatment rate in the experimental group(93.94%)was higher than reference group(73.76%),with statistically significant difference(P<0.05);the left ventricular fractional shortening rate in the experimental group was higher than reference group;left ventricular mass index(LVMI),left ventricular end-systolic diameter(LVESD),left ventricular end-diastolic diameter(LVEED)and left atrial diastolic diameter(LADD)values in the experimental group were smaller than reference group,with statistically significant difference(P<0.05);pro-brain natriuretic peptide(PRO-BNP)levels in the experimental group were better than reference group,with statistically significant difference(P<0.05);the adverse event rate in the experimental group(18.18%)was lower than reference group(27.27%),but without statistically significant difference(P>0.05);generic quality of life inventory(GQOLI)scores in the experimental group were higher than reference group,with statistically significant difference(P<0.05).Conclusion Metoprolol and candesartan can promote the fast rehabilitation,and improve the clinical effects and safety,cardiac function,PRO-BNP levels and patient’s quality of life.It is worthy of application and promotion.