甲基多巴配合硫酸镁在妊娠期高血压患者中应用效果及安全性分析

Analysis of the Efficacy and Safety of Methyldopa combined with Magnesium Sulfate in Patients with Hypertension During Pregnancy

目的探讨甲基多巴配合硫酸镁在妊娠期高血压患者中应用效果及安全性。方法选取我院2020年1月-2021年8月间收治的62例妊娠期高血压患者随机分为研究组(n=31)以及对照组(n=31)。对照组采取硫酸镁治疗,研究组在此基础上联合甲基多巴治疗,对比两组患者舒张压、收缩压、中心静脉压以及心脏指数水平。比较两组患者不良妊娠结局以及用药安全性情况。结果治疗前,两组患者舒张压以及收缩压水平比较差异无统计学意义(P>0.05);治疗后,两组患者舒张压以及收缩压水平存在不同幅度下降,但研究组水平要明显低于对照组(P<0.05)。治疗前,两组患者中心静脉压以及心脏指数水平比较差异无统计学意义(P>0.05);经过治疗后,两组患者中心静脉压存在不同幅度下降,但研究组水平更低(P<0.05);两组患者心脏指数水平存在不同幅度下降,但研究组水平更高(P<0.05)。研究组不良妊娠结局发生率(3.23%)较对照组(25.81%)更低(P<0.05)。研究组不良反应发生率(6.45%)较对照组(29.03%)更低(P<0.05)。结论甲基多巴配合硫酸镁治疗妊娠期高血压可获得较好的效果,降压效果显著,不良妊娠结局发生率较低,且不良反应较少,安全性较为理想。

Objective To investigate the effect and safety of methyldopa combined with magnesium sulfate in patients with hypertension during pregnancy.Methods 62 patients with hypertension during pregnancy admitted to our hospital from January 2020 to August 2021 were randomly divided into a study group(n=31)and a control group(n=31).The control group was treated with magnesium sulfate,and the study group was combined with methyldopa treatment on this basis.The diastolic blood pressure,systolic blood pressure,central venous pressure and cardiac index levels of the two groups were compared.The adverse pregnancy outcome and the safety of medication were compared between the two groups.Results Before treatment,there was no significant difference in the diastolic and systolic blood pressure between the two groups of patients(P>0.05).After treatment,the diastolic and systolic blood pressure levels of the two groups of patients decreased in different ranges,but the level of the study group was significantly lower in the control group(P<0.05).Before treatment,there was no significant difference in the levels of central venous pressure and cardiac index between the two groups of patients(P>0.05).After treatment,the central venous pressure of the two groups of patients decreased in different ranges,but the level of the study group was lower(P<0.05).The heart index levels of the two groups of patients decreased in different ranges,but the level of the study group was higher(P<0.05).The incidence of adverse pregnancy outcomes in the study group(3.23%)was lower than that in the control group(25.81%)(P<0.05).The incidence of adverse reactions in the study group(6.45%)was lower than that in the control group(29.03%)(P<0.05).Conclusion Methyldopa combined with magnesium sulfate can achieve good results in the treatment of hypertension during pregnancy,the effect of lowering blood pressure is significant,the incidence of adverse pregnancy outcomes is low,and the adverse reactions are fewer,and the safety is relatively ideal.