甲状腺结节细针穿刺液基细胞学检测的病理特征及临床诊断价值

Pathological Characteristics and Clinical Diagnostic Value of Fine Needle Puncture Fluid-based Cytology in Thyroid Nodules

目的分析甲状腺结节细针穿刺液基细胞学检测的病理特征及临床诊断价值。方法本文纳入观察对象有60例,全部都是2019年11月至2020年11月收治的经彩超检查确诊的甲状腺结节患者,60例患者均接受细针穿刺细胞涂片与细针穿刺液基细胞学技术制片检测。对比分析两种方法的检测结果。结果60例患者中,甲状腺恶性病变有11例,占比为18.33%;良性病变有49例,占比为81.67%。液基细胞学检测阴性组的恶性肿瘤发生率为4.17%(2/48),明显低于阳性组恶性肿瘤发生率75.00%(9/12),差异有统计学意义(P<0.05)。甲状腺结节细针穿刺检测中良性与恶性病变准确率为80.00%(48/60),特异度为81.82%(9/11),敏感度为77.55%(38/49),阳性预测值为79.17%(38/48),阴性预测值为83.33%(10/12)。结论细针穿刺液基细胞学检测用于甲状腺结节的检查效果理想,可及时确诊甲状腺良性结节与恶性结节,为临床治疗方案的制定提供依据,临床可进一步推广运用。

Objective To analyze the pathological features and clinical diagnostic value of fine needle puncture fluid-based cytology of thyroid nodules.Methods There were 60 cases of thyroid nodules diagnosed by color ultrasound from November 2019 to November 2020,to compare and analyze the test results of the two methods.Results Of the 60 patients,there were 11 malignant thyroid lesions,accounting for 18.33%;there were 49 benign lesions,accounting for 81.67%.The incidence of malignant tumor was 4.17%(2/48).It was significantly lower than 75.00%(9/12),with significantly statistic difference(P<0.05).The accuracy of benign and malignant lesions was 80.00%(48/60)in fine needle puncture of thyroid nodules,the specificity was 81.82%(9/11),sensitivity was 77.55%(38/49),and the positive predictive value was 79.17%(38/48).The negative predictive value was 83.33%(10/12).Conclusion The fine needle puncture liquid-based cytology test is ideal for the examination of thyroid nodules,which can diagnose benign and malignant thyroid nodules in time,provide the basis for the formulation of clinical treatment plan,and can be further popularized and applied in clinic.