脑出血后急性脑水肿予以托拉塞米和呋塞米的效果对比

Effect Comparison of Torasemide and Furosemide on Acute Brain Edema After Intracerebral Hemorrhage

目的探讨分别采取托拉塞米以及呋塞米药物对脑出血后急性脑水肿患者进行治疗后获得临床效果。方法将雷州市人民医院2017年6月-2020年5月收治的52例脑出血后急性脑水肿患者按数字奇偶法分组,托拉塞米组(26例)采用托拉塞米药物治疗,呋塞米组(26例)采用呋塞米药物治疗;就组间颅内压变化、周围脑水肿面积、颅内血肿面积、ADL评分以及NIHSS评分展开对比。结果治疗前,托拉塞米组患者颅内压变化同呋塞米组比较差异不明显(P>0.05);治疗后,托拉塞米组颅内压水平低于呋塞米组明显(P<0.05);治疗前,托拉塞米组患者周围脑水肿面积、颅内血肿面积同呋塞米组比较差异不明显(P>0.05);治疗后,托拉塞米组周围脑水肿面积、颅内血肿面积均小于呋塞米组明显(P<0.05);治疗前,托拉塞米组患者ADL评分以及NIHSS评分同呋塞米组比较差异不明显(P>0.05);治疗后,托拉塞米组ADL评分高于呋塞米组,NIHSS评分及低于呋塞米组,差异明显(P<0.05)。结论同呋塞米药物比较,托拉塞米药物有效应用,可使脑出血后急性脑水肿患者颅内压变化获得显著改善,可将周围脑水肿面积、颅内血肿面积显著降低,将ADL评分以及NIHSS评分显著改善,最终实现脑出血后急性脑水肿患者有效预后。

Objective To explore clinical effect of torasemide and furosemide in treatment of patients with acute brain edema after intracerebral hemorrhage.Methods The paper chose 52 cases acute brain edema patients after intracerebral hemorrhage in our hospital from June 2017 to may 2020,and divided them into two groups with digital parity method.Torasemide group(26 cases)was treated with torasemide,and furosemide group(26 cases)with furosemide.Results Before treatment,intracranial pressure changes in torasemide group were not significantly different from furosemide group(P>0.05);after treatment,level of intracranial pressure in torasemide group was significantly lower than furosemide group(P<0.05).Before treatment,there was no significant difference in area of peripheral brain edema and intracranial hematoma between torasemide group and furosemide group(P>0.05);after treatment,area of peripheral brain edema and intracranial hematoma in torasemide group was significantly smaller than furosemide group(P<0.05);before treatment,there was no significant difference in ADL scores and NIHSS scores between torasemide group and furosemide group(P>0.05).After treatment,ADL and NIHSS scores in torasemide group were significantly higher and lower than furosemide group(P<0.05)Conclusion Compared with furosemide,effective application of torasemide can significantly improve intracranial pressure changes of patients with acute brain edema after intracerebral hemorrhage,reduce area of peripheral brain edema and intracranial hematoma significantly,improve ADL and NIHSS scores,and achieve effective prognosis of patients with acute brain edema after intracerebral hemorrhage finally.