早期联合使用阿托伐他汀对创伤性颅脑损伤后硬脑膜下积液影响分析

Effect Analysis of Early Combined Application of Atorvastatin on Subdural Effusion after Traumatic Brain Injury

目的观察早期联合使用阿托伐他汀对创伤性颅脑损伤后硬脑膜下积液的影响。方法选取200例于2017年1月-2020年10月来南京市六合区人民医院就诊的TSH患者,随机分为观察组(n=100)和对照组(n=100)。对照组接受常规保守治疗,观察组在对照组基础上早期联合阿托伐他汀治疗。比较两组患者治疗前后的硬膜下积液量、炎症因子相关血清学指标,记录两组患者预后不良情况。结果治疗1个月后,两组硬膜下积液量均低于治疗前(P<0.05),但两组组间差异无统计学意义(P>0.05);与治疗前相比,两组治疗后的TNF-α、MMP-9、hs-CRP水平均更低;同时,与对照组相比,观察组也更低(P<0.05)。观察组复发及发展成CSDH者显著低于对照组(P<0.05)。结论基于常规治疗情况下,TSE患者早期联合阿托伐他汀治疗可显著减少硬膜下积液量,同时血清炎性因子水平降低,改善TSE预后。

Objective To observe effect of early combined application of atorvastatin on subdural effusion after traumatic brain injury.Methods The paper chose 200 cases TSH patients in to our hospital from January 2017 to October 2020 and divided them into observation group(n=100)and control group(n=100)randomly.Control group was treated with routine conservative treatment,and observation group with atorvastatin on the basis of control group.Amount of subdural effusion and serum indexes related to inflammatory factors were compared between two groups before and after treatment,and poor prognosis of two groups was recorded.Results After one month of treatment,the of subdural effusion in two groups was lower than before(P<0.05),there was no significant difference between two groups(P>0.05);TNF-αafter treatment in two groups,levels of MMP-9 and hs CRP were lower than before;at the same time,those of observation group were lower than control group(P<0.05).Recurrence and development of CSDH in observation group was significantly lower than control group(P<0.05).Conclusion Based on routine treatment,early combined treatment with atorvastatin can significantly reduce amount of subdural effusion of of TSE patients,reduce level of serum inflammatory factors and improve prognosis of TSE.