卡贝缩宫素防治高危妊娠产后出血的疗效及对PAP,Fib,D-D水平的影响

The Efficacy of Carbetocin in the Prevention and Treatment of Postpartum Hemorrhage in High-risk Pregnancy and its Influence on the Levels of PAP,Fib and D-D

目的探讨卡贝缩宫素防治高危妊娠产后出血的疗效及对PAP,Fib,D-D水平的影响,为临床实践提供理论依据。方法选取高危妊娠者90例为对象,45例应用地塞米松联合卡前列素氨丁三醇治疗,视为对照组,45例添加卡贝缩宫素治疗,视为试验组,研究时间为2019年5月至2020年5月,对比两组患者治疗效果,进行统计学分析。结果试验组给药前、给药30min的心率、舒张压、收缩压水平与对照组比较,差异无统计学意义,P>0.05。试验组患者在给药后24h的PAP水平、Fib水平、D-D水平均优于对照组,差异有统计学意义,P<0.05。试验组术中出血量、产后2h与产后24h的出血量明显低于对照组,差异有统计学意义,P<0.05。试验组不良反应发病率更低,与对照组比较,差异有统计学意义,P<0.05。结论高危妊娠采用卡贝缩宫素治疗,有助于改善凝血指标,降低产后出血量,预防产后出血,且并发症少,安全性高,具有显著治疗效果。

Objective To explore the efficacy of carbetocin in preventing and treating postpartum hemorrhage in high-risk pregnancy and its influence on the levels of PAP,Fib,and D-D to provide a theoretical basis for clinical practice.Methods Ninety cases of high-risk pregnancies were selected as subjects.45 cases were treated with dexamethasone combined with carboprost tromethamine and regarded as the control group,and 45 cases were treated with carbetocin and regarded as the experimental group.This study began in May 2019 and ended in May 2020,and the treatment effects of the two groups of patients were compared and statistically analyzed.Results The heart rate,diastolic blood pressure,and systolic blood pressure levels of the experimental group before administration and 30 minutes of administration were compared with those of the control group,and the difference was not statistically significant,P>0.05.The PAP level,Fib level,and D-D level of patients in the experimental group were better than those in the control group at 24 hours after administration,and the difference was statistically significant P<0.05.The amount of blood loss during the operation and the blood loss at 2h and 24h postpartum in the experimental group were significantly lower than those in the control group.The difference was statistically significant,P<0.05.Compared with the control group,the incidence of adverse reactions in the experimental group was lower,and the difference was statistically significant,P<0.05.Conclusion The treatment of high-risk pregnancy with carbetocin helps to improve the coagulation index,reduce the amount of postpartum hemorrhage,prevent postpartum hemorrhage,and has fewer complications,high safety,and a significant therapeutic effect.