他克莫司联合308nm准分子激光用于白癜风治疗的效果观察

Effect Observation of Tacrolimus Combined with 308nm Excimer Laser in Treatment of Vitiligo

目的探究他克莫司联合308nm准分子激光用于白癜风治疗的效果。方法选取2018年3月至2019年4月天水四〇七医院收治的白癜风患者115例,采用随机数字表法分为A组与B组,B组给予他克莫司,A组在B组基础上联合308nm准分子激光照射。治疗12周及20周后分别对疗效进行评价,并对比2治疗期间不良反应发生情况。结果治疗12周及20周,A组治疗总有效率分别为85.96%、98.25%,均高于B组的70.69%、86.21%,差异有统计学意义(P<0.05);2组均未出现严重不良反应,未影响治疗进程。结论他克莫司联合308nm准分子激光可提高白癜风治疗效果,且安全性良好。

Objective To explore effect of tacrolimus combined with 308nm excimer laser in treatment of vitiligo.Methods The paper chose 115 cases vitiligo patients admitted to Tianshui No.407 Hospital from March 2018 to April 2019,and divided them into group A and B randomly.group B was treated with tacrolimus,and group A with 308nm excimer laser irradiation on the basis of group B.Treatment effect was evaluated after 12 weeks and 20 weeks,and incidence of adverse reactions was compared between two groups.Results After 12 and 20 weeks of treatment,total effective rate of group A was 85.96%and 98.25%respectively,higher than 70.69%and 86.21%of group B,difference showed statistical significance,(P<0.05);there were no serious adverse reactions between both groups,which did not affect treatment process.Conclusion Tacrolimus combined with 308nm excimer laser can improve curative effect of vitiligo with good safety.