老年抑郁患者的焦虑及抑郁水平与血糖、血脂的相关性

Correlation of Anxiety and Depression Levels with Blood Sugar and Blood Lipids in Elderly Patients with Depression

目的探讨老年抑郁障碍患者的焦虑、抑郁水平与血糖、血脂之间的关系。方法2019年2月至2020年7月对73例的老年抑郁障碍患者及75名正常对照组检验血脂、血糖水平,汉密尔顿抑郁量表(Hamilton Depression Scale,HAMD)、汉密尔顿焦虑量表(Hamilton Anxiety Scale,HAMA)评定患者的抑郁和焦虑症状。结果老年抑郁障碍组血糖(GLU)、低密度脂蛋白(LDL-C)、甘油三酯(TG)及总胆固醇(TC)水平均明显高于对照组(P<0.05),高密度脂蛋水平虽低于对照组(P>0.05),但差异不具有统计学意义;老年抑郁障碍组的HAMD及HAMA评分均与血清中的TG、GLU水平正相关(P<0.05);患者组的HAMD(P<0.05)及HAMA(P>0.05)评分与血清HDL-C水平负相关。结论老年抑郁患者的焦虑及抑郁情绪与其血糖及血脂水平之间存在相关性,可能在老年抑郁障碍的疾病发生及发展过程中起到一定作用。

Objective To investigate the relationship between anxiety and depression level and blood sugar and blood lipid in elderly patients with depressive disorder.Methods The blood lipid and blood glucose levels were tested in 73 elderly patients with depressive disorder and 75 normal controls from February 2019 to July 2020.The Hamilton Depression Scale(HAMD)and Hamilton Anxiety Scale(HAMA)assessed the symptoms of depression and anxiety.Results The levels of blood glucose(GLU),low density lipoprotein(LDL-C),triglyceride(TG)and total cholesterol(TC)in the elderly depressive disorder group were significantly higher than those in the control group(P<0.05).The level of high density lipoprotein was lower than that of control group(P>0.05).But the difference is not statistically significant.The HAMD and HAMA scores of senile depressive disorder group were positively correlated with serum TG,GLU level(P<0.05).The HAMD(P<0.05)and HAMA(P>0.05)scores were negatively correlated with serum HDL-C levels.Conclusion There is a correlation between anxiety and depression and blood glucose and blood lipid levels in elderly depressive patients,which may play a role in the occurrence and development of senile depressive disorders.