超敏C反应蛋白结合降钙素原检测在诊断儿童肺部感染中的应用价值

Application Value of High Sensitivity C-Reactive Protein Combined With Procalcitonin in Diagnosis of Pulmonary Infected Children

目的分析超敏C反应蛋白(hs-CRP)结合降钙素原(PCT)检测在儿童肺部感染中的诊断价值,为临床儿童肺部感染早期诊断提供参考。方法选取2018年5月至2019年3月间于山东省千佛山医院接受诊断和治疗的儿童肺部感染患而96例,分成感染细菌组和感染非细菌组,选择同期入院接受健康体检的正常儿童46例作对照组。检测各组血清hs-CRP、PCT水平,然后绘制出各组儿童血清hs-CRP、PCT检测结果的特征曲线。结果感染细菌组与感染非细菌组血清hs-CRP、PCT水平各为(19.98±3.78)mg/L、(3.81±0.72)mg/L、(3.98±0.33)μg/L、(0.23±0.09)μg/L,检测结果都显著高于正常儿童对照组(t=4.899、3.017,5.131、4.156,均P<0.05);感染细菌组与感染非细菌组检测结果阳性率也都显著高于对照组(χ2=48.770、21.332、54.731、25.895,均P<0.05)。感染细菌组患者血清hs-CRP、PCT水平明显高于感染非细菌组(t=4.369、2.895,均P<0.05);感染细菌组阳性率明显高于感染非细菌组(χ2=40.657、48.291,均P<0.05)。当hs-CRP取5mg/L为临界值时,敏感度为69.56%,特异度为80.13%;当PCT取5μg/L为临界值时,敏感度为84.48%,特异度为89.02%。结论血清hs-CRP结合PCT检测在儿童肺部感染的早期诊断中具有重要价值,具有临床推广应用价值。

Objective To analyze diagnostic value of high sensitivity C-reactive protein(hs-CRP)combined with procalcitonin(PCT)for pulmonary infection children,to provide reference for early diagnosis of pulmonary infection children.Methods The paper chose 96 cases pulmonary infection children diagnosed and treated in Shandong Qianfoshan Hospital from May 2018 to March 2019,divided them into bacterial infection group and non bacterial infection group,and 46 cases normal children for physical examination at the same period as control group.The paper detected levels of serum hs-CRP and PCT in each group,and drew characteristic curves of serum hs-CRP and PCT.Results Serum levels of hs-CRP and PCT in bacterial infection group and non bacterial infection group were(19.98±3.78)mg/L,(3.81±0.72)mg/L,(3.98±0.33)μg/L,(0.23±0.09)μg/L respectively,which were significantly higher than control group(t=4.899,3.017,5.131,4.156,all P<0.05);positive rates of bacterial infection group and non bacterial infection group were significantly higher than control group(χ2=48.770,21.332,54.731,25.895,all P<0.05).Serum levels of hs-CRP and PCT in bacterial group were significantly higher than non bacterial group(t=4.369,2.895,all P<0.05);positive rate of bacterial group was significantly higher than non bacteria group(χ2=40.657,48.291,all P<0.05).When critical value of hs-CRP was 5mg/L,sensitivity and specificity was 69.56%and 80.13%respectively;when critical value of PCT was 5μg/L,sensitivity was 84.48%,and specificity was 89.02%.Conclusion Serum hs-CRP combined with PCT Detection has important value in early diagnosis of pulmonary infection children,which has clinical promotion and application value.