沙库巴曲缬沙坦对慢性心力衰竭患者心功能及运动耐力的影响研究

Study on the Effect of Salkubatrov on Cardiac Function and Exercise Tolerance in Patients with Chronic Heart Failure

目的分析在心力衰竭患者的治疗中,通过应用沙库巴曲缬沙坦治疗对患者心功能以及运动耐力等方面的影响。方法选取我院于2018年1月至2020年12月收治的慢性心力衰竭患者50例分析,随机分为两组,对照组在常规抗心力衰竭方案下治疗,观察组则在此基础上应用沙库巴曲缬沙坦。对两组患者的治疗情况进行观察,并对比各指标变化情况。结果观察组治疗有效率比对照组高,差异显著(P<0.05);观察组左心室收缩末期内径(LVESD)、左心室舒张末期内径(LVEDD)、左心室射血分数(LVEF)心功能指标改善水平比对照组高,6 min步行距离比对照组长,两组差异显著(P<0.05);观察组hs-CRP水平及NT-proBNP水平均比对照组低,差异显著(P<0.05);观察组不良反应率与对照组无明显差异,差异无统计学意义(P>0.05)。结论在慢性心力衰竭患者的治疗中,通过应用沙库巴曲缬沙坦治疗有助于促进患者心功能的改善,且能促进患者运动耐力的有效提升,临床疗效显著,值得推广应用。

Objective To analyze the effect of the treatment of heart failure patients with the application of salkubatra and valsartan on cardiac function and exercise tolerance.Methods Fifty patients with chronic heart failure in our hospital from January 2018 to December 2020 were selected and analyzed.They were randomly divided into two groups.The control group was treated with conventional anti heart failure scheme,while the observation group was treated with salkubatrov and valsartan on this basis.The treatment of the two groups were observed,and the changes of each index were compared.Results The effective rate of the observation group was higher than that of the control group,the difference was significant(P<0.05).The improvement level of left ventricular end systolic diameter(LVESD),left ventricular end diastolic diameter(LVEDD),left ventricular ejection fraction(LVEF)and cardiac function indexes of the observation group was higher than that of the control group,and the 6min walking distance was longer than that of the control group,the difference was significant(P<0.05).The hs-CRP level and NT-proBNP level of the observation group were lower than those of the control group,and the difference was significant(P<0.05).There was no significant difference in the adverse reaction rate between the observation group and the control group,the difference was not statistically significant(P>0.05).Conclusion In the treatment of patients with chronic heart failure,the application of sakubatro valsartan can help to improve the heart function of patients,and can promote the effective improvement of exercise endurance of patients,with significant clinical effect,which is worthy of promotion and application.