二甲双胍联合利拉鲁肽治疗肥胖2型糖尿病有效性的临床观察

Clinical Observation of Metformin Combined with Liraglutide in the Treatment of Obesity Type 2 Diabetes Mellitus

目的探究分析对肥胖2型糖尿病患者采取二甲双胍联合利拉鲁肽治疗的有效性和临床应用价值。方法选择160例肥胖2型糖尿病患者纳入本组研究,对其展开不同治疗形式的分组治疗探讨。对照组(80例)患者单纯应用二甲双胍治疗,实验组(80例)患者在二甲双胍治疗基础上加用利拉鲁肽联合治疗,对比两种不同治疗方式治疗前后血糖水平、体重指数、血脂及血压水平。结果①临床用药效果对比:实验组治疗后的临床总体疗效高于对照组;②各项血糖指标和体重指数的对比:治疗后,实验组患者的血糖、体重指数改善效果优于对照组;③各项脂质水平对比:治疗后,实验组患者的TC、TG、LDL-C和HDL-C指标改善均优于对照组;④血压水平对比治疗后,实验组患者的的SBP和DBP改善效果优于对照组。以上数据经对比均显示P<0.05。结论二甲双胍联合利拉鲁肽治疗不仅能够有效降低肥胖2型糖尿病患者的血糖,还能降低患者的体重指数、血脂及血压水平。

Objective To explore and analyze the efficacy and clinical application value of metformin combined with liraglutide in obese patients with type 2 diabetes.Methods One hundred and sixty cases of obese patients with type 2 diabetes were selected and divided into different groups.The control group(80 cases)was treated with metformin alone,while the experimental group(80 cases)was treated with liraglutide on the basis of metformin treatment.The blood glucose level,body mass index,blood lipid and blood pressure levels before and after treatment were compared.Results①Comparison of clinical medication effect:the overall clinical efficacy of the experimental group was higher than that of the control group.②Comparison of various blood glucose indexes and body mass index:after treatment,the improvement effect of blood glucose and body mass index of the experimental group was better than that of the control group.③Comparison of various lipid levels:after treatment,the improvement of TC,TG,LDL-C and HDL-C indexes of the experimental group were excellent.④After the treatment of blood pressure level,the improvement effect of SBP and DBP in the experimental group was better than that in the control group.The above data by comparison showed that P<0.05.Conclusion Metformin combined with liraglutide can not only effectively reduce the blood glucose of obese patients with type 2 diabetes,but also reduce the body mass index,blood lipid and blood pressure.