外泌体应用于激素性股骨头坏死诊疗的相关性研究进展

Research Progress on the Application of Exosomes in the Diagnosis and Treatment of Steroid Induced Osteonecrosis of the Femoral Head

激素性股骨头坏死是一种常见骨科慢性疾病,具有高致残率,发病后会严重影响患者的生活质量,且发病呈年轻化趋势。因此,早期对激素性股骨头坏死的诊断及治疗显得格外重要。外泌体是由细胞分泌的直径约30~100 nm的囊泡状物,可以介导细胞间的信号传递,调节体内局部微环境,促进组织损伤修复。外泌体为疾病的早期诊断、预防及治疗提供了新的策略,对激素性股骨头坏死的诊疗具有重要的意义。本文就外泌体与激素性股骨头坏死的相关研究进展做一综述,以期为其在激素性股骨头坏死诊疗中的进一步研究提供借鉴及依据。

Steroid induced osteonecrosis of the femoral head is a common chronic orthopedic disease,which has a high disability rate.After the onset,it will seriously affect the quality of life of patients,and the incidence is younger.Therefore,the early diagnosis and treatment of steroid induced osteonecrosis of the femoral head are particularly important.Exosomes are vesicles with a diameter of about 30~100 nm secreted by cells,which can mediate the signal transmission between cells,regulate the local microenvironment in vivo,and promote the repair of tissue damage.It provides a new strategy for the early diagnosis,prevention and treatment of the disease,and is of great significance for the diagnosis and treatment of steroid induced osteonecrosis of the femoral head.This article reviews the research progress of exosomes and steroid induced osteonecrosis of the femoral head,in order to provide reference and basis for its further research in the diagnosis and treatment of steroid induced osteonecrosis of the femoral head.