老年自身免疫性肝炎的临床检验特点分析

Clinical Characteristics of Autoimmune Hepatitis in the Elderly

目的探讨老年自身免疫性肝炎(AIH)患者临床中的检验特点。方法选取我院2013年1月至2018年12月收治的AIH患者共计103例作为临床研究对象,对其资料进行回顾性分析,将其按照年龄区间分组,60岁及以上的老年人44例记为老年组,其余59例不足60岁患者记为非老年组。对比两组患者血细胞指标、生化指标、肾脏功能指标、抗体阳性率及免疫球蛋白水平。结果老年组患者MC、MCH指标显著高于非老年组患者,P<0.05;两组患者各血生化指标对比均无显著差异性,P>0.05;两组患免疫球蛋白水平对比无显著差异性存在,P>0.05;两组患者Cr、Cys-c及Urea指标对比差异显著,老年组患者显著高于非老年组,P<0.05。结论老年AIH的诊断要结合血生化、抗体阳性情况及IgG水平进行综合判断,而对于非老年患者,更多关注DsDNA水平具有诊断意义。

Objective To investigate the clinical characteristics of elderly patients with autoimmune hepatitis(AIH).Methods A total of 103 patients with AIH in our hospital from January 2013 to December 2018 were selected as the clinical research objects,and their data were retrospectively analyzed.They were grouped according to the age range.Forty-four cases of elderly people aged 60 years and above were recorded as the elderly group,and the remaining 59 cases less than 60 years old were recorded as the non elderly group.Blood cell index,biochemical index,renal function index,antibody positive rate and immunoglobulin level were compared between the two groups.Results The indexes of MC and MCH in the elderly group were significantly higher than those in the non elderly group,P<0.05.There was no significant difference in the blood biochemical indexes between the two groups,P>0.05.There was no significant difference in the level of immunoglobulin between the two groups,P>0.05.There were significant differences in Cr,Cys-C and urea indexes between the two groups,and the elderly group was significantly higher than the non elderly group,P<0.05.Conclusion The diagnosis of AIH in the elderly should be combined with blood biochemistry,antibody positive situation and IgG level.For non elderly patients,more attention should be paid to the level of DsDNA.