分析喹诺酮联合三子养亲汤治疗慢阻肺急性加重期的临床疗效

Analysis of the Clinical Effect of Quinolone Combined with Sanzi Yangqin Decoction in the Treatment of Acute Exacerbation of COPD

目的分析研究针对急性加重期慢阻肺疾病(AECOPD),采用喹诺酮联合三子养亲汤的临床疗效,以及用药安全性。方法选取我院2009年1月至2020年5月内科收治的350名慢阻肺患者,将所有患者按照治疗方法的不同,分为175例对照组和175例观察组,分别采用喹诺酮类(莫西沙星)治疗和喹诺酮联合三子养亲汤治疗。比较两组患者的临床疗效。结果(1)临床疗效观察分析:观察组临床疗效良好,75例患者中有66例显效,8例有效,1例无效;对照组75例患者中有62例显效,11例有效,2例无效。所有药物治疗无效的患者在后续的手术治疗中恢复,现已出院。观察组患者治疗总有效率98.7%与对照组97.3%相比,差异无统计学意义(P>0.05)。(2)并发症发生率观察分析:观察组并发症发生例数2例,其中2例为血小板减少,无头痛和皮肤过敏出现;对照组发生例数11例,其中11例为血小板减少,无头痛,皮肤过敏症状。观察组总并发症率2.7%明显低于对照组14.7%,差异有统计学意义(P<0.05)。(3)比较两组患者的血压、心率、血氧动脉饱和度SaO2指标:观察组患者的血压、心率、血氧动脉饱和度SaO2指标显著优于对照组,且差异有统计学意义(P<0.05)。结论喹诺酮联合三子养亲汤治疗AECOPD患者疗效好,并发症少,值得推广应用。

Objective To analyze and study the clinical efficacy and safety of quinolone combined with Sanzi Yangqin Decoction for COPD.Methods Three hundred and fifty patients with COPD admitted in our hospital from January 2009 to may 2020 were divided into 175 control group and 175 observation group according to different treatment methods.They were treated with quinolones(moxifloxacin)and quinolones combined with Sanzi Yangqin Decoction respectively.The clinical effects of the two groups were compared.Results(1)Observation and analysis of clinical efficacy:the clinical efficacy of the observation group was good,66 cases were markedly effective,8 cases were effective,and 1 case was invalid.In the control group,62 cases were markedly effective and 11 cases were effective.2 cases were invalid.All patients who failed to respond to drug therapy recovered in the follow-up surgery and have been discharged.The total effective rate of the observation group was 98.7%,compared with 97.3%of the control group,the difference was not statistically significant(P>0.05).(2)Observation and analysis of complication rate:there were 2 cases of complications in the observation group,of which 2 cases were thrombocytopenia without headache and skin allergy.Eleven cases in the control group were thrombocytopenia,without headache and skin allergy symptoms.The total complication rate of the observation group(2.7%)was significantly lower than that of the control group(14.7%)(P<0.05).(3)Blood pressure,heart rate,SaO2 index of blood oxygen saturation were compared between the two groups:the SaO2 indexes of blood pressure,heart rate and blood oxygen saturation in the observation group were significantly better than those in the control group,and the difference was statistically significant(P<0.05).Conclusion Quinolone combined with Sanzi Yangqin decoction is effective and less complication in the treatment of AECOPD,which is worthy of promotion and application.