小剂量米氮平合并帕罗西汀治疗广泛性焦虑障碍效果分析

Effect Analysis Of Low-dose Mirtazapine Combined With Paroxetine In Treatment Of Generalized Anxiety Disorder

目的探讨小剂量米氮平合并帕罗西汀治疗广泛性焦虑障碍效果分析。方法将2018年8月至2019年8月在我院心身医学科治疗的80例广泛性焦虑障碍患者随机分为两组,对照组单用帕罗西汀治疗,观察组使用小剂量米氮平合并帕罗西汀治疗,对比两组的疗效、HAMA评分及BPRS评分变化、不良反应情况。结果观察组治疗有效率为95%,明显高于对照组的75%(P<0.05);观察组治疗后1周、2周、4周、6周、8周的HAMA评分、BPRS评分均明显低于对照组(P<0.05);观察组口干、嗜睡、头晕、便秘、恶心、心动过速、体重增加等不良反应发生率与对照组相比无明显差异(P>0.05)。结论小剂量米氮平合并帕罗西汀治疗广泛性焦虑障碍效果显著,能减轻焦虑程度,改善精神症状,且不良反应发生率可控,具有积极的临床意义。

Objective To investigate effect of low-dose mirtazapine combined with paroxetine in treatment of generalized anxiety disorder.Methods We chose 80 cases of generalized anxiety disorder patients treated in psychiatric department of our hospital from August 2018 to August 2019,divided them into two groups randomly.Control group was treated with paroxetine only,and observation group with low-dose mirtazapine combined with paroxetine treatment.Compare curative effect,HAMA and BPRS scores changes,and adverse reactions between two groups.Results Effective rate of treatment in observation group was 95%,which was significantly higher than 75%in control group(P<0.05);HAMA scores and BPRS scores of observation group after 1 week,2 weeks,4 weeks,6 weeks,and 8 weeks of treatment were significantly lower than control group(P<0.05);observation group showed no significant difference in incidence of adverse reactions such as dry mouth,drowsiness,dizziness,constipation,nausea,tachycardia,weight gain compared with control group(P>0.05).Conclusion Low-dose mirtazapine combined with paroxetine can achieve significant effect in treating generalized anxiety disorder,reduce anxiety and improve mental symptoms,with controllable incidence of adverse reactions,which is of positive clinical significance.