探讨血清淀粉样蛋白A(SAA)和C-反应蛋白(CRP)联合检测在小儿感染性疾病鉴别诊断中的应用价值

To Investigate the Value of Serum Amyloid A(SAA) and C-reactive Protein(CRP) in Differential Diagnosis of Infectious Diseases in Children

目的研究血清淀粉样蛋白A(SAA)和C-反应蛋白(CRP)联合检测在小儿感染性疾病鉴别诊断中的应用价值。方法入组对象为我院2019年6月至2019年10月收治的536例小儿感染性疾病患儿,将其作为研究组,并选取同期健康儿童500名作为参照组。采用免疫散射比浊法和免疫荧光分析法对两组儿童的血清淀粉样蛋白A(SAA)和C-反应蛋白(CRP)进行检测,探讨SAA和CRP联合检测诊断小儿感染性疾病的价值。结果两组检测结果显示,研究组患儿的SAA指标中位数显著高于参照组儿童,组间比较有显著差异(P<0.05)。两组CRP指标检测结果比较,研究组高于参照组,组间差异明显(P<0.05)。研究组肺炎感染患儿的SAA和CRP的检测阳性率分别为70.00%和52.00%,急性支气管炎感染的SAA和CRP检测阳性率分别为92.25%和85.27%,急性阑尾炎感染的SAA和CRP检测阳性率均为100.00%,急性胆囊炎感染的SAA和CRP检测阳性率均为100.00%,急性胰腺炎感染的SAA和CRP检测阳性率分别为88.12%和81.19%,其中急性阑尾炎和急性胆囊炎检测阳性率为100%,略高于其他疾病。结论采用血清淀粉样蛋白A(SAA)和C-反应蛋白(CRP)联合检测,可以对小儿感染性疾病进行准确的诊断,并能够对临床疾病进行有效的分型。

Objective To investigate the value of combined detection of serum amyloid A(SAA)and C-reactive protein(CRP)in the differential diagnosis of infectious diseases in children.Methods 536 children with infantile infectious diseases were admitted in our hospital from june 2019 to october 2019 as the study group,and 500 healthy children were selected as the reference group in the same period.The serum amyloid A(SAA)and C-reactive protein(CRP)of the two groups of children were detected by immunoscattering turbidimetry and immunofluorescence analysis to explore the value of combined detection of SAA and CRP in the diagnosis of infectious diseases in children.Results The results of the two groups showed that the median SAA index in the study group was significantly higher than that in the reference group(P<0.05).The results of the two groups of CRP indexes were compared,the study group was higher than the reference group,and the difference between the two groups was obvious(P<0.05).The positive rates of SAA and CRP were 70.00%and 52.00%,respectively.The positive rates of SAA and CRP were 92.25%and 85.27%,respectively.The positive rates of SAA and CRP were 100.00%,respectively.The positive rate of SAA and CRP for acute cholecystitis infection was 100.00%,and the positive rate of SAA and CRP for acute pancreatitis infection was 88.12%and 81.19%,respectively.Conclusion The combination of serum amyloid A(SAA)and C-reactive protein(CRP)can make an accurate diagnosis of infectious diseases in children and can effectively classify clinical diseases.