不同血清肿瘤标志物联合检测在老年肺癌早期诊断中的临床价值

Clinical Value of Combined Detection of Different Serum Tumor Markers in the Early Diagnosis of Lung Cancer in the Elderly

目的研究老年肺癌早期诊断中通过不同血清肿瘤标志物联合检测的价值及应用。方法选取我院就诊的300例肺癌患者,分为肺癌组与良性肺病组,采用不同血清肿瘤标志物联合测定,观察并分析多种血清肿瘤标志物联合诊断老年肺癌早期的应用价值。结果相较于良性肺病组,肺癌组血清NSE、CEA、CA50和CYFRA21-1水平明显更高(P<0.05),肺癌组血清NSE、CEA、CA50和CYFRA21-1阳性诊断率明显高于良性肺病组,同时4项血清肿瘤标志物联合检测的阳性率远高于其他单项诊断结果。结论在老年肺癌早期诊断中使用不同血清肿瘤标志物联合诊断,能够显著降低漏诊和误诊情况,提高老年肺癌早期的诊断水平。

Objective To study the value and application of combined detection of different serum tumor markers in the early diagnosis of lung cancer in the elderly.Methods Three hundred patients with lung cancer in our hospital were divided into lung cancer group and benign lung disease group.The combined detection of different serum tumor markers was used to observe and analyze the application value of multiple serum tumor markers in the early diagnosis of lung cancer in the elderly.Results Compared with the benign lung disease group,the serum NSE,CEA,CA50 and CYFRA21-1 levels in the lung cancer group were significantly higher(P<0.05).The positive diagnosis rate of NSE,CEA,CA50 and CYFRA21-1 in the lung cancer group was significantly higher than that in the benign lung disease group,and the positive rate of the combined detection of the four serum tumor markers was much higher than that of other single diagnosis results.Conclusion The use of different serum tumor markers in the early diagnosis of lung cancer in the elderly can significantly reduce missed diagnosis and misdiagnosis,and improve the diagnosis level of lung cancer in the elderly.