甲硝唑联合克林霉素治疗细菌性阴道炎的临床效果观察

Clinical Effect of Metronidazole Combined with Clindamycin in the Treatment of Bacterial Vaginitis

目的探讨对细菌性阴道炎患者临床使用甲硝唑联合克林霉素进行治疗后,相关疗效指标的提升情况。方法对选定的45例接受单纯使用甲硝唑治疗的患者(对照组)与45例临床使用甲硝唑联合克林霉素进行的治疗的患者(观察组)进行相关疗效指标的数据统计和比较。所选样本进行比较分析的指标包括:治疗总有效率;不良药物反应发生率。结果观察组患者临床治疗总有效率达到91.11%(41例),明显高于对照组(32例,71.11%);观察组患者在用药后出现食欲不振患者1例、眩晕1例、未发生腹部绞痛,不良药物反应总发生率为4.44%,低于对照组(食欲不振患者4例、眩晕3例、腹部绞痛1例,17.78%)。结论对细菌性阴道炎患者,临床采用甲硝唑与克林霉素联合治疗,患者愈后复发率低、不良药物反应小,能够更好地改善患者的临床症状、提高治疗效果。

Objective To discuss the improvement of clinical efficacy of metronidazole combined with clindamycin in patients with bacterial vaginitis.Methods In this study,45 patients who were treated with metronidazole alone(control group)and 45 patients who were treated with metronidazole combined with clindamycin(observation group)were compared.The indexes of comparative analysis include total effective rate of treatment and incidence of adverse drug reaction.Results The total clinical effective rate of the patients in the observation group was 91.11%(41 cases),which was significantly higher than that in the control group(32 cases,71.11%).In the observation group,there were 1 case of anorexia,1 case of vertigo and no abdominal colic.The total incidence of adverse drug reactions was 4.44%,which was lower than that of the control group(4 cases of anorexia,3 cases of vertigo,1 case of abdominal colic,17.78%).Conclusion For patients with bacterial vaginitis,metronidazole and clindamycin were treated with metronidazole combined with clindamycin,the recurrence rate was low and the adverse drug reaction was small,which could improve the clinical symptoms and therapeutic effect of the patients.