甲硝唑联合克林霉素治疗细菌性阴道炎临床疗效观察

Clinical Observation of Metronidazole combined with Clindamycin in the Treatment of Bacterial Vaginosis

目的观察甲硝唑联合克林霉素治疗细菌性阴道炎的临床疗效。方法选择2018年1月到2019年2月我院收治的122例诊断为细菌性阴道炎的患者,随机将其分为观察组和对照组各61例,对照组单纯给予甲硝唑进行治疗,观察组在对照组基础上联合应用克林霉素进行治疗,对比分析两组临床治疗效果。结果观察组总有效率为95.08%,显著优于对照组的75.41%,两组比较差异有统计学意义(P<0.05);观察组不良反应发生率与对照组比较差异无显著性(P>0.05)。结论甲硝唑联合克林霉素治疗细菌性阴道炎临床疗效确切,具有较高安全性,值得临床推广应用。

Objective To observe the clinical efficacy of metronidazole combined with clindamycin in the treatment of bacterial vaginosis. Methods 122 patients with bacterial vaginosis admitted to the hospital from January 2018 to February 2019 were randomly divided into observation group and control group, 61 cases were in each group. The control group was treated with metronidazole while the observation group was given clindamycin on the basis of the control group. The clinical effects of the two groups were compared and analyzed. Results The total effective rate of the observation group was 95.08%, which was significantly better than 75.41% of the control group(P<0.05). The incidence of adverse reactions in the observation group had no significantly different from the control group(P>0.05). Conclusion Metronidazole combined with clindamycin in the treatment of bacterial vaginitis is clinically effective and safe. It is worthy of clinical application.