镇痛镇静用于ICU重症脓毒血症患者治疗中的临床效果观察

Clinical Effect Observation of Analgesia and Sedation in Treatment of ICU Severe Sepsis Patients

目的观察镇痛镇静用于ICU重症脓毒血症患者治疗中的临床效果。方法选择我院2017年4月至2018年11月内收诊的62例ICU重症脓毒血症患者作为对象,按照1:1比例采用随机数表法进行分组,设为对照组和研究组,各组31例,其中,对照组病人应用硫酸吗啡缓释片镇痛剂,研究组病人应用枸缘酸芬太尼注射液+咪达唑仑注射液,观察比较临床镇静、镇痛效果。结果(1)镇静效果,研究组镇静时间及停药后唤醒时间都长于对照组(P<0.05);(2)血液流变学指标,研究组治疗后血浆黏度、红细胞聚集指数以及红细胞变形指数和全血还原黏度与对照组差异显著,有统计学意义(P<0.05);(3)镇痛效果,研究组治疗后VAS评分低于对照组,差异具备统计学意义(P<0.05)。结论ICU重症脓毒血症,枸缘酸芬太尼注射液+咪达唑仑注射液镇痛镇静治疗,疗效确切,值得推广。

Objective to observe clinical effect of analgesia and sedation in treatment of severe sepsis ICU patients.Methods choose 62 cases severe sepsis ICU patients from April 2017 to November 2018 in our hospital as objects.Divide them into control group and study group according to ratio of 1:1.31 cases in each group.Control group were treated with morphine sulfate sustained-release tablet pain suppressor,and study group with fentanyl citrate injection+midazolam injection.Observe and compare clinical sedative and analgesic effects.Results①sedative effect,sedative time and wake-up time of study group was longer than control group(P<0.05);②hemorheological indexes,plasma viscosity,RBC aggregation index,RBC deformation index and whole blood reduced viscosity of study group was significantly different from control group,with statistical significance,(P<0.05);③analgesic effect,VAS scores of study group were lower than control group,difference was statistically significant(P<0.05).Conclusion fentanyl citrate injection plus midazolam injection can achieve accurate effect on severe sepsis ICU patients,which is worthy of promotion.