摘要
驱钩新化合物王苯双脒(Tribendimidin)用鼠伤寒沙门氏菌/微粒体酶系统检测,对TA 97,TA98,TA 100及TA 102菌株未见诱变性。小鼠ig 500 mg/kg后24 h的骨髓微核试验结果为阴性,未见染色体畸变。培养的中国仓鼠肺成纤维细胞系的染色体畸变试验也为阴性。孕大鼠于d 8~d 10每日ig 200 mg/kg,未见有胚胎毒性及致畸性。
A new broad-spectrum anthelmintic agent tribendimidin wasstudied for its mutagenicity and teratogenicity.No mutagenic effect was obser-ved by the following three tests:Salmonella/microsome system with TA 97,TA 98,TA100 and TA 102;micronucleus test in NIH mice administered up to500 mg/kg(about 1/2 LD50);in vitro chromosomal aberration test with Chinesehamster lung fibroblast cell line.No evidence of external and internal malfor-mations and skeletal deformities were observed in pregnant rats administeredorally up to daily dose of 200 mg/kg from d8 to d10 of gestation.
出处
《医药工业》
CAS
1988年第3期112-115,共4页
关键词
抗蠕虫药
三苯双脒
诱变性
致畸性
anthelmintics
tribendimidin
mutagenicity
teratogenicity
