1-乙酰-4-(4-羟基苯基)哌嗪合成的改进

IMPROVED PREPARATION OF 1-ACETYL 4-(4-HYDROXYPHENYL)PIPERAZINE

二乙醇胺经溴化、环合一锅合成N-(4-甲氧苯基)哌嗪氢溴酸盐(3),解决了劳动保护问题。酰化收率经改进从26%提高至70%以上,总收率26.4%,适合工业生产。

An improved preparation of the title compound was achievedfrom diethanolamine and 4-aminoanisole via bromination-cyclization in one pot,followed by demethylation and acetylation in an overall yield of 26.4%.