10-乙酰蒽林和蒽林的色谱分析及其稳定性研究

THE CHROMATOGRAPHY OF 10-ACETYLANTHRALIN AND ANTHRALIN AND ITS APPLICATION FOR CHEMICAL STABILITY STUDY

本文研究了10-乙酰蒽林(3)与蒽林(2)的色谱分离法。3,2与2中的主要杂质1,8-二羟基蒽醌(1),可经 TLC、柱层析及 HPLC 使三者得到很好的分离。根据化学动力学的线性变温法,用 HPLC 研究了3及2溶液的化学稳定性,结果表明3比2稳定。

The chromatography of 10-acetylanthralin(3)and anthralin(2)was studied.By TLC,column chromatography and HPLC techniques,3,2,and danthron(1)were separated efficiently from one other.The chemical stability by the methodof chemical kinetic technique and HPLC was studied.The E,k,k,(?),τwere determined.It was shown that 10-acetylanthralin was more stable thananthralin.