道地药材药理学与道地药材标准构建新思路

Dao-di herbs pharmacology and new ideas of Dao-di herbs standard construction

道地药材药理学(Dao-di herbs pharmacology)是以中医药基本理论为指导,运用现代科学方法,研究道地药材的性质、性能、与机体相互作用规律及其临床运用规律的一门学科。道地药材药理学是道地药材基础研究和临床转化应用桥梁科学,对于客观描述道地药材药效作用规律,科学阐释道地药材药效机制,探索建立基于生物效应和临床疗效的道地药材标准和方法,为道地药材的药性理论、药理作用机制和临床价值提供科学依据。进一步作者提出基于疗效而非产地的道地药材标准构建新设想,道地药材标准应源于传统,前提是基于传统产区道地药材的系统研究,通过环境、遗传、性状、化学、药理等特征的提取,形成新的道地药材技术标准。这种标准源于传统,但高于传统,可能已不具有严格意义的行政区划的产地含义,但更能体现道地药材药理学特征和优良临床价值。

Guided by the basic theory of traditional Chinese medicine and using modern scientific methods,Dao-di herbs pharmacology studies the nature,performance,interaction with the body and its clinical application.It is a bridge between the basic research and clinical application of Dao-di herbs.It can objectively describe the law of efficacy of Dao-di herbs,scientifically explain the mechanism of efficacy of Dao-di herbs,explore and establish the standards and methods of Dao-di herbs based on biological effect and clinical efficacy,and provide scientific basis for the special properties,pharmacology and clinical value of Dao-di herbs.Furthermore,we put forward a new idea of building the standard of Dao-di herbs based on the curative effect rather than the origin.The Dao-di herbs standard should come from the systematic research of traditional Dao-di herbs producing areas and form a new characteristic system,through the extraction of environmental,genetic,character,chemical,pharmacological and other characteristics.This standard originates from the tradition,but it is higher than the tradition.It may not have the origin meaning of strict administrative division,but it can better reflect the pharmacological characteristics and excellent clinical value of Dao-di herbs.