紫堇中1个新的降倍半萜苷类化合物

A new nor-sesquiterpene glycoside from Corydalis edulis

研究紫堇Corydalis edulis的化学成分。利用大孔吸附树脂D101,硅胶,ODS,Sephadex LH-20和半制备HPLC等色谱方法分离纯化,结合其理化性质和MS,NMR,UV,IR等谱学数据鉴定化合物的结构。从紫堇的乙醇提取物二氯甲烷和水萃取部位分离并鉴定了4个化合物,分别为6′-β-D-xylosylicariside B2(1),(3S,5R,6S,7E)-5,6-epoxy-3-hydroxy-7-megastigmen-9-one(2),黑麦草内酯(3),5,5′-dimethoxybiphenyl-2,2′-diol(4)。其中,化合物1为新化合物,并通过计算ECD的方法确定其绝对构型,化合物4为首次从罂粟科植物中分离得到,化合物2和3为首次从紫堇属植物中分离得到。

This study is to investigate the chemical constituents from the whole plant Corydalis edulis.The chemical constituents were separated and purified by macroporous resin D101,silica gel,Sephadex LH-20,ODS,and semi-preparative HPLC.Their structures were determined by physicochemical properties and spectroscopic data.Four compounds were isolated from the dichloromethane and water extracts of the whole plant C.edulis,and identified as 6′-β-D-xylosylicariside B2(1),(3S,5R,6S,7E)-5,6-epoxy-3-hydroxy-7-megastigmen-9-one(2),loliolide(3),and 5,5′-dimethoxybiphenyl-2,2′-diol(4),respectively.Compound 1 is a new compound,of which the absolute configuration was established by electronic circular dichroism(ECD)calculations.Compound 4 is obtained from the plants of Papaveraceae family for the first time.Compounds 2 and 3 are firstly isolated from the Corydalis genus.