天名精属植物的倍半萜类成分及其药理活性研究进展

Research progress on sesquiterpenes and its pharmacological activities in genus Carpesium

天名精属植物中含有多种倍半萜类成分,迄今为止从该属植物的全草及果实中至少发现了201个倍半萜类化合物,其中吉马烷型倍半萜86个,桉叶烷型倍半萜30个,愈创木烷型倍半萜29个,倍半萜二聚体23个,伪愈创木烷型倍半萜9个,卡拉布烷型倍半萜9个,苍耳烷型倍半萜7个,无内酯环倍半萜6个,艾里莫芬烷型倍半萜1个,十二烷型倍半萜1个。研究表明这些倍半萜具有多种药理活性,包括抗肿瘤,抗炎,抗菌,抗寄生虫,杀虫,抗病毒等。该文对天名精属植物中的201个倍半萜类化合物及其生物活性进行分类归纳,以期为天名精属植物的深入研究与应用开发提供参考。

The genus Carpesium plants contain many kinds of sesquiterpenes.Up to now,more than 201 sesquiterpene compounds have been isolated and identified,including 86 germacranolides,30 eudesmanolides,29 guaianolides,23 sesquiterpene dimers,9 pseudoguaianes,9 carabranolides,7 xanthanolides,6 sesquiterpenes without lactone,1 eremophilane and 1 tricyclo dodecane sesquiterpene.The reported sesquiterpenes possess a series of pharmacological properties,such as anti-tumor,anti-inflammatory,antibacterial,antiparasitic,insecticidal,and antiviral activities.This paper summarizes the 201 chemical structures and biological activities of sesquiterpenes in genus Carpesium,and provides the scientific basis for the further development and utilization.