鸦胆子油乳注射液联合酒石酸长春瑞滨和顺铂化疗对肺癌患者术后康复的影响

Effect of brucea javanica oil emulsion injection combined with chemotherapy with vinorelbine tartrate and cisplatin on postoperative recovery in patients with lung cancer

目的探讨鸦胆子油乳注射液联合酒石酸长春瑞滨和顺铂(NP化疗)对肺癌患者免疫功能、凝血及肺功能的影响。方法选取2018年9月至2019年9月间黄浦区肿瘤防治院收治的进行治疗的104例肺癌患者作为研究对象。按照治疗方法不同进行分组,其中采用NP化疗的52例患者纳入对照组,采用鸦胆子油乳注射液联合NP化疗的52例患者纳入观察组。比较两组患者化疗效果、治疗前后免疫功能(CD3^+、CD4^+、CD8^+、CD4^+/CD8^+水平)、凝血功能[凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB)、凝血酶原活动度(PTA)、血浆D-二聚体(D-D)和血小板(Plt)]以及肺功能[用力肺活量(FVC%)、第一秒用力呼出量(FEV 1%)和一氧化碳弥散能力(DLCO%)]。结果观察组患者肿瘤控制率为88.5%,明显高于对照组患者的71.2%,差异有统计学意义(P<0.05)。两组患者治疗后CD3^+、CD4^+和CD4^+/CD8^+水平均降低,CD8^+水平升高。观察组CD3^+、CD4^+和CD4^+/CD8^+水平高于对照组,CD8^+水平低于对照组,差异均有统计学意义(均P<0.05)。治疗前,两组患者PT、APTT、FIB、PTA、D-D和Plt比较,差异无统计学意义(P>0.05)。治疗后,观察组FIB和Plt水平明显较治疗前和对照组低,差异均有统计学意义(均P<0.05);两组患者PT、APTT、PTA和D-D水平比较,差异无统计学意义(P>0.05)。两组患者治疗后FEV1%水平明显较治疗前高,且观察组FEV1%水平明显高于对照组,差异均有统计学意义(均P<0.05)。结论鸦胆子油乳注射液联合NP化疗治疗肺癌有助于提高免疫功能,改善凝血功能和肺功能,值得临床推广。

Objective To explore the effect of brucea javanica oil emulsion injection combined with vinorelbine tartrate and cisplatin(NP chemotherapy)on immune function,coagulation and lung function in patients with lung cancer.Methods A total of 104 patients with lung cancer who were treated at Shanghai Huangpu District Cancer Prevention and Treatment Hospital from September 2018 to September 2019 were selected as the study subjects.According to the therapies they received,52 patients who received brucea javanica oil emulsion injection combined with NP chemotherapy were include in an observation group and 52 patients who only received NP chemotherapy were included in a control group.The efficacy of chemotherapy,the levels of immune function(CD3^+,CD4^+,CD8^+and CD4^+/CD8^+),coagulation function[prothrombin time(PT),activated partial thromboplastin time(APTT),fibrinogen(FIB),prothrombin activityprothrombin time activity(PTA),D-dimer(D-D)and platelets(PLT)]and lung function[forced vital capacity(FVC)%,forced expiratory volume in 1 second(FEV1)%,diffusing capacity of the lungs for carbon monoxide(DLCO)%]were compared.Results The tumor control rate was 88.5%in the observation group which was significantly higher than 71.2%of the control group(P<0.05).After treatment,the levels of CD3^+,CD4^+and CD4^+/CD8^+decreased and CD8^+increased in both groups with the levels of CD3^+,CD4^+and CD4^+/CD8^+higher in the observation group than in the control group,and the levels of CD8^+lower in the observation group than in the control group(all P<0.05).There was no significant difference in the levels of Pt,APTT,FIB,PTA,D-D and Plt between the two groups before the treatment(P>0.05).After the treatment,the levels of FIB and Plt were significantly lower in the observation group than in the control group compared with before the treatment(P<0.05).There was no significant difference in the levels of PT,APTT,PTA and D-D between the two groups(P>0.05).The FEV1%level was significantly higher in the two groups after the treatment compared with before the treatment with the observastion group higher than the control group(all P<0.05).Conclusion Brucea javanica oil emulsion injection combined with NP chemotherapy in the treatment of lung cancer is helpful to improve the immune function,coagulation function and lung function,which is worthy of clinical promotion.