肿瘤切除术后肝动脉介入化疗栓塞术治疗原发性肝癌患者的血清肿瘤标志物和生存情况研究

Serum tumor markers and survival in patients with primary liver cancer undergoing TACE after tumor resection

目的探讨肿瘤切除术后肝动脉介入化疗栓塞术(TACE)治疗原发性肝癌患者的血清肿瘤标志物及生存情况。方法选取2014年1月至2016年7月间资阳市安岳县人民医院收治的行肿瘤切除术的64例原发性肝癌患者,采用随机数表法分为研究组和对照组,每组32例。两组患者均行常规肿瘤切除术,研究组患者术后2个月内行TACE治疗,比较两组患者治疗结束后血清肿瘤标志物水平,随访复发率和生存率。结果治疗后,研究组患者甲胎蛋白异质体(AFP-L3)、甲胎蛋白(AFP)、磷脂酰肌醇蛋白聚糖-3(GPC3)和高尔基体蛋白-73(GP73)含量均低于对照组,差异均有统计学意义(均P<0.05)。研究组患者1年复发率和2年复发率均低于对照组,差异均有统计学意义(均P<0.05);两组患者3年复发率比较,差异无统计学意义(P>0.05)。研究组患者1年生存率和2年生存率均高于对照组,差异均有统计学意义(均P<0.05);两组患者3年生存率比较,差异无统计学意义(P>0.05)。结论肿瘤切除术后行TACE治疗原发性肝癌患者,能有效降低患者肿瘤标志物水平,短期内有效降低复发率,提高生存率。

Objective To observe the serum tumor markers and survival in patients with primary liver cancer undergoing transcatheter arterial chemoembolization(TACE)after tumor resection.Methods Sixty-four patients with primary liver cancer who underwent tumor resection at Anyue County People’s Hospital from February 2014 to July 2016 were enrolled.The patients were divided into a study group 43 and a conventional group with 32 patients in each group.Both groups underwent conventional tumor resection.The study group underwent TACE within 2 months after the surgery.Serum tumor markers were compared between the two groups at the end of the treatment.They were followed for recurrence rate and survival rate.Results The serum alpha-fetoprotein heterogeneity(AFP-13),alpha-fetoprotein(AFP),glypican-3(GPC3)and Golgi protein 73(GP73)were significantly lower in the study group than in the conventional group(all P<0.05).The 1-year and 2-year recurrence rates were significantly lower in the study group than in the conventional group(all P<0.05).There was no significant difference in the 3-year survival between the two groups(P>0.05).The 1-year and 2-year survival rates were significantly higher in the study group than in the conventional group(all P<0.05).There was no significant difference in the 3-year survival between the two groups(P>0.05).Conclusion TACE after tumor resection can effectively reduce the tumor markers and recurrence rate and improve the survival rate.