紫杉醇注射液对子宫颈癌患者血清肿瘤标志物的影响

Effect of paclitaxel injection on serum TNF,IL-8 and TSGF in patients with uterine cancer

目的探讨紫杉醇注射液对子宫颈癌患者血清肿瘤坏死因子(TNF)、白细胞介素-8(IL-8)和恶性肿瘤特异生长因子(TSGF)的影响。方法选取2017年1月至2019年3月间大连大学附属中山医院收治的78例子宫颈癌患者,采用随机数字表法分为研究组和对照组,每组39例。对照组患者采用常规手术及辅助性治疗,研究组患者在接受常规治疗前给予紫杉醇注射液,比较两组患者治疗前后血清IL-8、TNF和TSGF水平。结果治疗前,两组患者IL-8、TNF和TSGF水平比较,差异无统计学意义(P>0.05)。治疗后,研究组患者IL-8、TNF和TSGF水平和对照组患者TNF水平均较治疗前降低,且研究组均低于对照组,差异均有统计学意义(均P<0.05)。蛋白质印记法检测TNFR1蛋白,研究组患者TNFR1蛋白水平为(96.28±16.35)%,低于对照组的(63.28±6.29)%,差异有统计学意义(t=6.50,P<0.05)。结论紫杉醇注射液能抑制子宫颈癌诱导的IL-8、TNF和TSGF水平增加。

Objective To study the effects of paclitaxel injection on serum TNE,IL-8 and TSGF in patients with uterine cancer.Methods A total of 78 patients with uterine cancer admitted to Zhongshan Hospital Affiliated to Dalian University from January 2017 to September 2019 were enrolled in the study.They were randomly divided into a study group and a control group with 39 patients in each group.The patients in the study group were given paclitaxel injection before routine treatment.The patients in the control group underwent routine surgery and were given adjuvant therapy.The serum levels of interleukin-8(IL-8),tumor necrosis factor(TNF)and tumor specific growth factor(TSGF)were compared between the two groups before and after treatment.Results There was no significant difference in the levels of IL-8,TNF and TSGF between the two groups before treatment(P>0.05).The levels of IL-8,TNF and TSGF decreased in both groups after the treatment with the level lower in the study group than in the control group(all P<0.05).Protein imprinting was used to test the TNFR1 levels.The level of TNFR1 was 96.28±16.35%in the study group which was lower than 63.28±6.29%(t=6.50,P<0.05).Conclusion Paclitaxel injection can inhibit the increase of IL-8,TNF and TSGF induced by uterine cancer.