壮腰祛瘀方治疗腰椎间盘突出症术后残留症状的临床研究

Clinical Study of Zhuangyao Quyu Decoction in Treating Residual Symptoms after Operation of Lumbar Disc Herniation

目的:观察壮腰祛瘀方对腰椎间盘突出症术后残留症状的临床疗效,并探讨其可能的机制。方法:选取本院脊柱科诊断为LDH且行腰椎后路开放手术,术后有残留腰腿部疼痛麻木症状的70名住院患者,随机分为治疗组和对照组。分别于治疗前,治疗后7d,治疗后1个月和6个月对患者行VAS评分和JOA评分评定,并在治疗前和治疗后1个月时,应用酶联免疫吸附试验(ELISA)检测患者血清中IL-1β和TNF-α含量。结果:经过1个疗程壮腰祛瘀方治疗,各时间点的患者VAS和JOA评分明显改善,患者血清中IL-1β和TNF-α含量明显减低。结论:壮腰祛瘀方能改善LDH术后残留的腰腿部疼痛麻木患者的症状,其作用机制可能是通过降低体内IL-1β和TNF-α炎性因子来实现的。

Objective:To demonstrate the clinical efficacy and mechanism of the Zhuangyao Quyu decoction in treating residual symptoms after operation of lumbar disc herniation(LDH).Methods:70 hospitalized patients with residual symptoms after operation of LDH were enrolled in our hospital.They were randomly divided into treatment group and control group.The patients were assessed by VAS score and JOA score at the day before surgery,7 d,1 month and 6 months after treatment.The levels of IL-1βand TNF-αin serum were detected by enzyme-linked immunosorbent assay(ELISA)before and 1 month after treatment.Results:The VAS and JOA scores of the patients at each time point were significantly improved after a course of treatment.The serum levels of IL-1βand TNF-αwere significantly reduced.Conclusion:Zhuangyao Quyu decoction can significantly improve the residual symptoms of patients after operation of LDH,and its mechanism may be achieved by reducing IL-1βand TNF-αinflammatory factors in vivo.