伊格列净合成路线图解

Graphical synthetic routes to ipragliflozin

伊格列净(ipragliflozin,1),化学名为(1S)-1,5-脱水-1-C-[3-[(1-苯并噻吩-2-基)甲基]-4-氟苯基]-D-葡萄糖醇,分子式:C21H21FO5S,分子量:404.45,CAS登记号:761423-87-4。该药是由日本Astellas和Kotobuki公司研发的钠葡萄糖协同转运蛋白2(SGLT2)抑制剂类治疗2型糖尿病的药物,于2014年1月在日本批准上市。

Ipragliflozin w hose chemical name is(1 S)-1,5-anhydro-1-C-[3-[(1-benzo thiophene-2-yl)methyl]-4-fluorophenyl]-D-glucitol,and CAS is 761423-87-4.Ipragliflozin,a kind of SGLT2 inhibitor,w as jointly developed by Astellas and Kotobuki Pharmaceutical and received its first global approval for the treatment of type 2 diabetes mellitus in Japan in January 2014.It w as the first SGLT 2 inhibitor to be approved in Japan.Ipragliflozin has the advantages of good hypoglycemic effect and less adverse reaction.It can be used as monotherapy and in combination w ith other hypoglycemic drugs.