健康管理策略对绝经过渡期女性绝经相关症状临床干预效果研究

Effect of long-term health management strategy on menopausal related symptoms and quality of life of women with perimenopause

目的探讨长期健康管理策略对绝经过渡期女性绝经相关症状及生存质量的影响。方法选取2017年1~12月在浙江萧山医院接受管理的绝经过渡期女性116例,按照随机数字表法分为对照组(n=58)和观察组(n=58),对照组患者给予常规的激素替代治疗,观察组患者使用长期健康管理策略进行管理,对比两组患者干预前后绝经相关症状严重程度、性激素水平、生存质量、治疗效果和干预满意度。结果经过干预后,两组的绝经相关症状评分均降低,干预后的组间对比中,观察组的绝经相关症状评分均低于对照组[t=9.949(潮热出汗)、10.050(心脏不适)、11.253(睡眠问题)、8.383(情绪问题)、6.796(疲劳感)、15.050(性生活)、10.076(膀胱问题),P均<0.05]。经过干预后,两组的雌二醇均增高,卵泡刺激素和黄体生成素均降低,干预后的组间对比中,观察组的雌二醇高于对照组,卵泡刺激素和黄体生成素低于对照组[t=-5.065(雌二醇)、5.497(卵泡刺激素)、5.615(黄体生成素),P均<0.05]。经过干预后,两组的生存质量评分均降低,干预后的组间对比中,观察组的生存质量评分低于对照组(t=-5.695,P<0.05)。观察组的治疗效果优于对照组(Z=2.654,P<0.05)。对照组的干预满意率为63.79%,观察组的干预满意率为86.21%,数据差异有统计学意义(χ2=7.770,P<0.05)。结论使用长期健康管理策略干预绝经过渡期的女性,可以缓解绝经相关症状,稳定性激素水平,提升生存质量。

Objective To explore the effect of long-term health management strategies on menopausal related symptoms and quality of life of women with perimenopause.Methods A total of 116 women with perimenopause women treated ang managed in our hospital from January 2017 to December 2017 were selected.According to random number table method,they were divided into the control group(n=58)and the observation group(n=58).Women in the control group were given routine hormone replacement therapy,and those in the observation group received a long-term health management.The severity of menopausal symptoms,sex hormone levels,the quality of life,the therapeutic effects and the intervention satisfaction were evaluated and compared between the two groups before and after intervention.Results After intervention,the menopausal-related symptoms scores went down in both groups and the scores of hot flush,heart discomfort,sleep problem,emotional problem,fatigue,sexual life and bladder problem were all significantly lower in the observation group than those in the control group(t=9.949,10.050,11.253,3.383,6.796,15.050,10.076,P<0.05).After intervention,the levels of estradiol went up while the levels of follicle stimulating hormone and luteinizing hormone went down in both groups.Compared with the control group,the estradiol level in the observation group was significantly higher while the the follicle stimulating hormone and luteinizing hormone levels were significantly lower(t=-5.065,5.497,5.615,P<0.05).After intervention,the quality of life scores decreased in both groups and it was lower in the observation group than that in the control group(t=-5.695,P<0.05).The therapeutic effect was better in the observation group than that in the control group(Z=2.654,P<0.05)and the intervention satisfaction rate was higher in the observation group that that in the control group(86.21%vs 63.79%;χ~2=7.770,P<0.05).Conclusions Long-term health management can alleviate menopausal-related symptoms,stabilize hormone levels,and improve quality of life of women with perimenopause.