酒精性肝病与肠道菌群关系的研究进展

The relationship between alcoholic liver disease and intestinal flora

肠道菌群被认为是人体的"第二大脑",肝脏被称为人体内的"生化工厂",由于肠道与肝脏均起源于内胚层,且通过门静脉紧密相连,所以肝脏的各项机能都与肠道菌群息息相关。酒精性肝病是由于摄入酒精导致的慢性肝病之一,在全球范围内普遍存在。近年来的研究结果表明,酒精性肝病(alcoholic liver disease,ALD)的发生与发展与肠道菌群密切相关。本文就肠道菌群与ALD的关系作一综述,并对靶向肠道菌群治疗ALD的方法简要总结,以期对ALD的治疗提供新策略。

The intestinal flora is recognized as the "second brain" of the human body,while liver is known as the "biochemical factory" of human body. Since both the intestine and liver originate from the endoderm tissue and they are closely connected through the portal vein, therefore, various functions of the liver are closely related to intestinal flora. Alcoholic liver disease(ALD) is one of chronic liver diseases caused by intaking of alcohol, which is prevalent all over the world. It has been found out recently that the development of ALD is associated with the intestinal flora. In this article, we summarized the relationship between intestinal flora and ALD, and introduced new methods for the treatment of ALD through intestinal flora.