甲状腺髓样癌诊治中值得关注的几个问题

Key points for attention in diagnosis and treatment of medullary thyroid carcinoma

甲状腺髓样癌(medullary thyroid carcinoma,MTC)是甲状腺滤泡旁(C细胞)恶性增殖异常分化导致的恶性肿瘤。多数MTC会出现RET基因突变,该疾病缺乏特定的临床特点,病程进展迅速,易发生转移,预后相对较差。目前对于MTC的诊断标准、辅助检查及治疗方案等方面仍然存在争议与分歧,在治疗方面主要采取以外科手术为基础的综合治疗模式。

Medullary thyroid carcinoma(MTC)is a malignant tumor caused by abnormal proliferation and differentiation of para follicular thyroid cells(C cells).Most MTC patients will have mutations in RET gene.Lack of specific clinical characteristics of MTC,rapid course of disease,easy metastasis,the prognosis is relatively poor.At present,there are still controversies and differences in the diagnosis standard,auxiliary examination and treatment plan of MTC.The comprehensive treatment mode based on surgery is more appropriate.