稀土纳米诊疗试剂的研究进展与展望

Research and Frontiers in Rare-Earth-Based Nanoagents for Theranostics

稀土纳米材料作为一种新兴的多功能纳米诊疗试剂,因其光、电、磁、热等特性,具有荧光成像、X线CT成像及磁共振成像的功能,在癌症诊疗中具有重要的应用前景。如何将稀土纳米材料与其他功能材料结合,构建集医学疾病影像诊断、肿瘤定位和高效肿瘤治疗于一体的纳米诊疗试剂,实现诊疗一体化,是该领域面临的巨大挑战。精准合成、微结构调控及表面化学新型设计为融合稀土纳米材料用于肿瘤成像及原位治疗一体化技术提供了新的思路和策略。本文将简要介绍稀土纳米诊疗试剂的研究现状和进展,重点综述其在多模态成像和肿瘤治疗领域的应用,并对稀土纳米诊疗试剂的未来发展进行展望。

Rare earth nanomaterials have been developed as emerging theranostic nanoagents due to their unique optical,electrical,magnetic,and thermal properties.Based on these outstanding properties,rare earth nanomaterials display very promising applications in cancer theranostics,such as fluorescence imaging,X-ray CT imaging,and magnetic resonance imaging.However,it is still a major challenge to develop new type of rare earth nanomaterials for the integration of tumor diagnosis,localization,and treatment in a versatile way.Precise synthesis,microstructure modification,and novel surface chemical design of rare earth nanomaterials might provide new avenues for nanotheranostics applications.In this review,we first briefly introduce current progress of the rare earth theranostic nanoagents.Secondly,an overview of their applications in multimodal imaging and tumor therapy is given.Finally,we give a brief summary and perspective for the development of rare earth theranostic nanoagents.