摘要
近20年来,纳米材料及纳米技术在生物医学中的应用发展迅猛,为疾病的预防和治疗提供了巧妙且有效的解决方案。尤其在疫苗相关研究方面,基于纳米科学与技术,发展出了众多新型疫苗佐剂及疫苗递送系统,能有效提升疫苗的免疫激活能力、稳定性和生物安全性等,同时也为传统疫苗提供了更多附加功能,如pH响应等,为疫苗的创新研发设计与发展注入了新的活力。本文从疫苗佐剂和递送系统出发,综述纳米科学与技术在新型疫苗设计中的应用,为新型疫苗的后续研发提供参考。
In the past two decades,the application of nanomaterials and nanotechnology in biomedicine have developed rapidly,providing ingenious and effective solutions for the prevention and treatment of diseases.Especially in vaccine research,based on nanoscience and technology,several new vaccine adjuvants and vaccine delivery systems have been developed,which effectively promote the activation of immunity,stability,and safety.Besides,it offers traditional vaccines more additional functions,such as p H response,which has added more vitality to the design and development for the innovation of vaccine research.In this review,the application of nanoscience and nanotechnology in the design of novel vaccines based on adjuvant and delivery systems are summarized,expecting to provide a guide for future research and development.
作者
王馨
高素素
王亚玲
赵宇亮
陈春英
WANG Xin;GAO Susu;WANG Yaling;ZHAO Yuliang;CHEN Chunying(National Center for Nanoscience and Technology,Beijing 100190;University of Chinese Academy of Sciences,Beijing 100049;The GBA National Institute for Nanotechnology Innovation,Guangzhou 510700)
出处
《中国基础科学》
2022年第1期13-24,36,共13页
China Basic Science
基金
国家重点研发计划项目(2016YFA0201600)
政府间国际科技创新合作重点专项项目(2018YFE0117200)
国家自然科学基金项目(11621505,22027810)
中国科学院战略重点研究计划项目(XDB36000000)
关键词
纳米技术
疫苗
佐剂
nanotechnology
vaccine
adjuvant
