相位角与慢性阻塞性肺疾病的系统评价

The phase angle and chronic obstructive pulmonary disease:a systematic review

目的系统评价基于生物电阻抗的相位角是否与慢性阻塞性肺疾病(简称慢阻肺)患者的功能、严重程度与预后有关。方法检索PubMed、Embase、Web of Science、Scopus、CNKI和WanFang数据库的相关文献,按照标准进行文献筛选和数据提取。使用混合方法评价工具进行文献质量评价,提取结果相关的数据进行归纳总结,并以定性综合的形式做描述性分析。结果共计纳入11篇文献,包含2189名受试者,文献整体质量较高。3篇研究报道了相位角与慢阻肺严重程度的关联,8篇研究报道了相位角与慢阻肺肺功能和躯体功能的关联,7篇研究报道了相位角与慢阻肺住院时间、营养风险、急性加重和死亡等不良预后的关联。总体结果显示低相位角水平与慢阻肺患者病情严重、功能下降和不良预后有关,相位角是慢阻肺患者肺功能、躯体运动耐力、急性加重和死亡的独立预测因子。结论慢阻肺患者的相位角水平与其疾病严重程度、功能和预后效果相关,是慢阻肺患者临床管理有潜在价值的指标。

Objective To systematic investigate whether phase angle of bioelectrical impedance is associated with the functionality,severity,and prognosis of individuals afflicted with chronic obstructive pulmonary disease(COPD).Methods Relevant literature from the PubMed,Embase,Web of Science,Scopus,CNKI,and WanFang databases was retrieved,and literature screening and data extraction in accordance with standardized methods were conducted.Literature quality was assessed by utilizing Mixed Methods Appraisal Tool.Subsequently,data pertaining to the results was extracted for summarization and induction,and descriptive analyzed through qualitative synthesis.Results A total of 11 studies,encompassing 2189 subjects,were included in this review,and the overall quality of the literature was deemed relatively high.Of these studies,three examined the correlation between phase angle and the severity of COPD,eight studies examined the correlation between phase angle and pulmonary and physical function in COPD,and seven studies reported the association between phase angle and adverse outcomes such as hospitalization time,nutritional risk,acute exacerbation and mortality in COPD.The collective findings suggestted that reduced levels of phase angle are linked to severe illness,diminished function,and unfavorable prognosis among individuals with COPD.Phase angle emerged as an independent predictor of lung function,physical exercise endurance,acute exacerbation and mortality in COPD patients.Conclusion The phase angle level of COPD patients is associated with their disease severity,function,and prognosis,and is an potential available indicator for clinical management of COPD patients.