多囊卵巢综合征动物模型数据挖掘及分析

Data mining and analysis of an animal model of polycystic ovary syndrome

多囊卵巢综合征(polycystic ovary syndrome,PCOS)是一种病因不明的妇科代谢和内分泌紊乱疾病。探讨不同PCOS动物模型,可以揭示PCOS病因及评估防治措施。本文通过搜索中国知网以"多囊卵巢综合征+动物模型"和PubMed以"Polycystic ovary syndrome+animal model"为主题,排除综述类和理论性文献,确定1989-2018年间231篇用于PCOS动物包括啮齿类、非人灵长类和反刍动物模型的研究性论文。评估不同动物模型与人PCOS相似性,为PCOS疾病研究不同研究目的提供最佳模型。

Polycystic ovary syndrome(PCOS)is a gynecological metabolic and endocrine disorder of unknown etiology.Exploring different PCOS animal models might help reveal the etiology of PCOS and establish prevention and treatment measures.In this paper,we searched China National Knowledge Infrastructure(CNKI)for"polycystic ovary syndrome+animal model"and PubMed for"polycystic ovary syndrome+animal model",excluding reviews and theoretical literature.We found 231 articles from 1989 to 2018,and PCOS animals included research literature on rodent,non-human primate,and ruminant models.This study evaluated similarities between different animal models and human PCOS,to indicate the optimal model for different research purposes of PCOS disease research.