摘要
早发性卵巢功能不全(premature ovarian insufficiency,POI)是女性在40岁之前卵巢活动衰退的临床综合征,以月经紊乱并伴有高促性腺激素和低雌激素为特征。POI对女性的内分泌功能、生育能力甚至正常的生活都有着严重的不利影响,了解与POI相关的信号转导通路对阐释POI发病的原因、恢复卵巢功能、寻找潜在的药物治疗靶点和诊疗新技术具有重要的意义。本文综述了与POI相关的信号通路研究进展,重点介绍了转化生长因子β(transforming growth factor-β,TGF-β)超家族信号通路、PI3K-AKT和Hippo信号通路。
Premature ovarian insufficiency(POI)is a clinical syndrome characterized by menstrual disorders accompanied by high gonadotropin and low estrogen in women under the age of 40.POI causes destructive damage to a woman’s endocrine function,fertility and even normal life.Understanding the signal transduction pathways related to POI is of great significance in explaining the causes of POI,restoring ovarian function and finding potential drug treatment targets and new therapeutic technologies.In this review,we summarize the recent research advances of POI-related signaling pathways,mainly focusing on the transforming growth factor-β(TGF-β)superfamily,PI3K-AKT and Hippo signaling pathways.
作者
李德保
周莉
孙祖越
LI Debao;ZHOU Li;SUN Zuyue(National Evaluation Centre for the Toxicology of Fertility Regulating Drugs,Shanghai Institute of Planned Parenthood Research,Shanghai 200032,China;School of Pharmacy,Fudan University,Shanghai 201203;Key Laboratory of Reproduction Regulation of NPFPC,Shanghai 200032;Reproductive and Developmental Research Institute of Fudan University,Shanghai 200032)
出处
《中国比较医学杂志》
CAS
北大核心
2020年第2期121-127,共7页
Chinese Journal of Comparative Medicine
基金
国家科技重大专项(2018ZX09201017-002)
上海市科委研发平台专项(17DZ2293600).
