信号转导和转录活化因子3在妊娠期肝内胆汁淤积症孕妇胎盘中的表达及护理

Expression and Nursing of Signal Transduction and Transcription Activator 3 in Placenta of Pregnant Women with Intrahepatic Cholestasis during Pregnancy

目的研究信号转导和转录活化因子3在妊娠期肝内胆汁淤积症孕妇胎盘中的表达并进行护理措施分析。方法2017年2月1日-2019年2月28日医院收治的肝内胆汁淤积症孕妇90例作为病变组,病变组孕妇按照随机抽签法等分成观察组及对照组,采用免疫组织化学法检测2组胎盘组织中的信号转导和转录活化因子3表达水平,并进行对比,对照组实施常规护理,观察组则予以预见性护理干预。比较2组护理后谷丙转氨酶、总胆红素、总胆汁酸水平,分娩结局,围生儿结局以及阿氏评分。另随机抽取同期健康顺产孕妇90例作为健康组。结果病变组信号转导和转录活化因子3细胞阳性率与平均光密度值均高于健康组(均P<0.05)。观察组谷丙转氨酶、总胆红素、总胆汁酸水平水平均低于对照组(均P<0.05)。观察组剖宫产人数占比低于对照组,而阴道分娩人数占比高于对照组(均P<0.05)。观察组围生儿宫内窘迫、新生儿窒息发生率均低于对照组,而阿氏评分高于对照组(均P<0.05)。结论信号转导和转录活化因子3可能参与了妊娠期肝内胆汁淤积症的发生、发展过程,预见性护理干预可有效改善妊娠结局以及围生儿结局,具有较高的临床推广应用价值。

Objectives To study the expression of signal transduction and transcriptional activation factor 3 in placenta of pregnant women with intrahepatic cholestasis during pregnancy and analyze the nursing measures.Methods 90 cases of intrahepatic cholestasis during pregnancy pregnant women admitted to our hospital from February 2017 to February 2019 were included as the lesion group,and another 90 cases of healthy vaginal delivery were selected as the healthy group.Immunohistochemistry was used to detect the level of signal transduction and transcriptional activation factor 3 in the placental tissues of the two groups and then compared.In addition,pregnant women in the lesion group were divided into observation group and control group according to the random lottery method.Control group to implement routine nursing,observation group to predict nursing intervention.ALT,TBIL and TBA levels,parturient outcome,perinatal outcome and Apgar score were compared between the two groups.Results The positive rate and average optical density of signal transduction and transcriptional activation factor 3 cells in the pathological group were higher than those in the healthy group(all P<0.05).ALT,TBIL and TBA levels in the observation group were lower than those in the control group(all P<0.05).The proportion of cesarean section in the observation group was lower than that in the control group,while the proportion of vaginal delivery was higher than that in the control group(all P<0.05).Apgar score was higher than that of control group(P<0.05).Conclusions Signal transduction and transcriptional activation factor 3 may be involved in the occurrence and development of intrahepatic cholestasis during pregnancy.Predictive nursing intervention could effectively improve pregnancy outcome and perinatal outcome,which had a high clinical application value.