肺淋巴管平滑肌瘤病肺部病变的影像学研究进展

Advances in imaging study of pulmonary lymphangioleiomyomatosis

淋巴管平滑肌瘤病(lymphangioleiomyomatosis,LAM)是一种罕见的特发性疾病,其主要累及器官为肺,即肺LAM(pulmonary LAM,PLAM),表现为两肺弥漫肺气囊。近年来PLAM的影像学研究及其进展迅速,包括CT图像中的肺气囊定量、纹理分析,PET-CT显示肺实质及淋巴病变等。基于CT的PLAM肺气囊半定量、全定量、组学分析等,不仅能够精准地反映PLAM患者肺内病变的范围,且与肺功能关联度高,为患者病情评估、疗效预测等提供了新方法。PET/CT及SPECT/CT能够较好地评估PLAM患者的淋巴系统病变情况。

Pulmonary lymphangioleiomyomatosis(PLAM)is a rare idiopathic disease,which mainly involves lung and presents with diffused lung cysts.This paper reviews the imaging study and research progress of PLAM in recent years,including the quantitative analysis,texture analysis in CT images based pulmonary balloon.PET/CT may shows lesions in pulmonary parenchyma or lymphatic system.The semi-quantitative,full quantitative and omics analysis of pulmonary balloons based on CT could reflect the range of pulmonary lesions,and has a positive correlation with pulmonary function,which provide new methods for disease assessment and curative efficacy prediction in the patients with PLAM.The PET/CT and SPECT/CT have better evaluation effectiveness for the lymphoid system lesions in PLAM patients.